2021-> Present
[1] Botana, L. M., Louzao, M. C., and Vilariño, N., (Eds.) (2021) Climate change and marine and freshwater toxins, 2nd Edition ed., De Gruyter, Berlin. Book
[2] Gegunde, S., Alfonso, A., Alvarino, R., Alonso, E., Gonzalez-Juanatey, C., and Botana, L. M. (2021) Crosstalk between cyclophilins and T lymphocytes in coronary artery disease, Exp. Cell Res. 400, 112514. DOI: 10.1016/j.yexcr.2021.112514
[3] Gegunde, S., Alfonso, A., Alvariño, R., Alonso, E., and Botana, L. M. (2021) Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions, Front. Immunol. 12. DOI: 10.3389/fimmu.2021.609196
[4] Louzao, M. C., Abal, P., Costas, C., Suzuki, T., Watanabe, R., Vilarino, N., Botana, A. M., M, R. V., and Botana, L. M. (2021) DSP Toxin Distribution across Organs in Mice after Acute Oral Administration, Mar. Drugs 19. DOI: 10.3390/md19010023
[5] Louzao, M. C., Vilariño, N., and Botana, L. M. (2021) Effects on world food production and security, In Climate change and marine and freshwater toxins (Botana, L. M., Louzao, M. C., and Vilariño, N., Eds.) 2nd ed., pp 579-606, De Gruyter, Berlin. Book Chapter
[6] Vilariño, N., Louzao, M. C., Fraga, M., and Botana, L. M. (2021) From science to policy: dynamic adaptation of legal regulations on aquatic biotoxins, In Climate change and marine and freshwater toxins (Botana, L. M., Louzao, M. C., and Vilariño, N., Eds.) 1st ed., pp 607-654, De Gruyter, Berlin. Book Chapter
[7] Klionsky, D. J., and 2300 authors, and Tong, C. K. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy, 1-382. DOI: 10.1080/15548627.2020.1797280
[8] Gonzalez-Jartin, J. M., Rodriguez-Canas, I., Alfonso, A., Sainz, M. J., Vieytes, M. R., Gomes, A., Ramos, I., and Botana, L. M. (2021) Multianalyte method for the determination of regulated, emerging and modified mycotoxins in milk: QuEChERS extraction followed by UHPLC-MS/MS analysis, Food Chem. 356, 129647. DOI: 10.1016/j.foodchem.2021.129647
[9] Boente-Juncal, A., Raposo-Garcia, S., Louzao, M. C., Vale, C., and Botana, L. M. (2021) Targeting Chloride Ion Channels: New Insights into the Mechanism of Action of the Marine Toxin Azaspiracid, Chem. Res. Toxicol. 34, 865-879. DOI: 10.1021/acs.chemrestox.0c00494
[10] Alvarino, R., Alonso, E., Tabudravu, J. N., Perez-Fuentes, N., Alfonso, A., and Botana, L. M. (2021) Tavarua Deoxyriboside A and Jasplakinolide as Potential Neuroprotective Agents: Effects on Cellular Models of Oxidative Stress and Neuroinflammation, ACS Chem. Neurosci. 12, 150-162. DOI 10.1021/acschemneuro.0c00626
[11] Greer, B.; Chevallier, O.; Quinn, B.; Botana, L. M.; Elliott, C. T., Redefining dilute and shoot: The evolution of the technique and its application in the analysis of foods and biological matrices by liquid chromatography mass spectrometry. TrAC Trends in Analytical Chemistry 2021, 141, 116284. DOI: 10.1016/j.trac.2021.116284
[12] Perez-Fuentes, N.; Alvarino, R.; Alfonso, A.; Gonzalez-Jartin, J.; Gegunde, S.; Vieytes, M. R.; Botana, L. M., Single and combined effects of regulated and emerging mycotoxins on viability and mitochondrial function of SH-SY5Y cells. Food Chem. Toxicol. 2021, 112308. DOI 10.1016/j.fct.2021.112308
[13] Gegunde, S.; Alfonso, A.; Alvariño, R.; Pérez-Fuentes, N.; Botana, L. M., Anhydroexfoliamycin, a Streptomyces Secondary Metabolite, Mitigates Microglia-Driven Inflammation. ACS Chem. Neurosci. 2021. DOI 10.1021/acschemneuro.1c00033
[14] Louzao, M. C.; Costas, C.; Abal, P.; Suzuki, T.; Watanabe, R.; Vilariño, N.; Carrera, C.; Boente-Juncal, A.; Vale, C.; Vieytes, M. R.; Botana, L. M., Serotonin involvement in okadaic induced diarrhoea in vivo. Arch Toxicol 2021. DOI 10.1007/s00204-021-03095-z
[15] Rubiolo, J. A.; Lence, E.; González-Bello, C.; Roel, M.; Gil-Longo, J.; Campos-Toimil, M.; Ternon, E.; Thomas, O. P.; González-Cantalapiedra, A.; López-Alonso, H.; Vieytes, M. R.; Botana, L. M., Crambescin C1 as a possible substrate candidate of iNOS and eNOS increasing nitric oxide production with an in vivo hypotensive effect. Front. Pharmacol. 2021. 12, 694639. DOI 10.3389/fphar.2021.694639
[16] Alves, C., Silva, J., Pinteus, S., Alonso, E., Alvarino, R., Duarte, A., Marmitt, D., Goettert, M. I., Gaspar, H., Alfonso, A., Alpoim, M. C., Botana, L. M., and Pedrosa, R. (2021) Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius, Molecules 26, 1374.
[17] Raposo-Garcia, S.; Louzao, M. C.; Fuwa, H.; Sasaki, M.; Vale, C.; Botana, L. M., Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels. Food and Chem Toxicol 2022, 160, 112812.
[18] Botana, L. M., Modo de acción de los fármacos. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 41-84. Book Chapter
[19] Vilariño, N., Fármacos que actúan sobre receptores colinérgicos. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 107-120. Book Chapter
[20] Vale, C., Boente-Juncal, A., Raposo-García, S., Fármacos que actúan sobre receptores de GABA y de Glutamato. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 149-168. Book Chapter
[21] Louzao, M.C., Fármacos que actúan sobre canales iónicos. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 169-194. Book Chapter
[22] Alfonso, A., González-Jarín, J.M., Fármacos que actúan sobre Receptores de Péptidos, neuropéptidos y hormonas peptídicas. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 195-212. Book Chapter
[23] Alfonso, A., Alvariño, R., Fármacos que actúan sobre Receptores de Peptidos opioides. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 213-226. Book Chapter
[24] Louzao, M.C., Fármacos que modulan la función de transportadores. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 247-264. Book Chapter
[25] Vilariño, N., Inmunomodulación y anticuerpos de uso terapéutico. In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas., Botana, L. M., Ed. Editorial Panamericana: Madrid, 2022; pp 455-465. Book Chapter
[26] Gonzalez-Jartin, J. M.; Ferreiroa, V.; Rodriguez-Canas, I.; Alfonso, A.; Sainz, M. J.; Aguin, O.; Vieytes, M. R.; Gomes, A.; Ramos, I.; Botana, L. M., Occurrence of mycotoxins and mycotoxigenic fungi in silage from the north of Portugal at feed-out. Int. J. Food Microbiol. 2022, 365, 109556.
[26] Alves, C., Silva, J., Afonso, M. B., Guedes, R. A., Guedes, R. C., Alvarino, R., Pinteus, S., Gaspar, H., Goettert, M. I., Alfonso, A., Rodrigues, C. M. P., Alpoim, M. C., Botana, L., and Pedrosa, R. (2022) Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models, Biomed. Pharmacother. 149, 112886. DOI 10.1016/j.biopha.2022.112886
[27] Louzao, M. C., Vilarino, N., Vale, C., Costas, C., Cao, A., Raposo-Garcia, S., Vieytes, M. R., and Botana, L. M. (2022) Current Trends and New Challenges in Marine Phycotoxins, Mar. Drugs 20. DOI 10.3390/md20030198
[28] Habauzit, D., Lemée, P., Botana, L. M., and Fessard, V. (2022) Toxicity Predictions for Mycotoxins: A Combined In Silico Approach on Enniatin‐Like Cluster, Exposure and Health. DOI 10.1007/s12403-022-00492-2
[29] Noirmain, F., Dano, J., Hue, N., Gonzalez-Jartin, J. M., Botana, L. M., Servent, D., Simon, S., and Aráoz, R. (2022) NeuroTorp, a lateral flow test based on toxin-receptor affinity for in-situ early detection of cyclic imine toxins, Anal. Chim. Acta 1221, 339941. DOI: 10.1016/j.aca.2022.339941
[30] Raposo-Garcia, S., Boente-Juncal, A., Rodriguez-Vieytes, M., Camina, M., Costas, C., Cao, A., Louzao, M. C., Cifuentes, M., Vale, C., and Botana, L. M. (2022) In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity, Arch. Toxicol. 96, 2621-2638. DOI: 10.1007/s00204-022-03315-0
[31] Perez-Fuentes, N., Alvarino, R., Alfonso, A., Gonzalez-Jartin, J., Gegunde, S., Vieytes, M. R., and Botana, L. M. (2022) Enniatins A1 and B1 alter calcium homeostasis of neuronal cells leading to apoptotic death, Food Chem. Toxicol. 168, 113361. DOI: 10.1016/j.fct.2022.113361
[33] Alvarino, R., Alfonso, A., Pech-Puch, D., Gegunde, S., Rodriguez, J., Vieytes, M. R., Jimenez, C., and Botana, L. M. (2022) Furanoditerpenes from Spongia (Spongia) tubulifera Display Mitochondrial-Mediated Neuroprotective Effects by Targeting Cyclophilin D, ACS Chem. Neurosci. 13, 2449-2463. DOI: 10.1021/acschemneuro.2c00208
[34] Alvariño, R., Alfonso, A., Perez-Fuentes, N., González-Jartín, J. M., Gegunde, S., and Vieytes, M. R. (2022) Extracellular cyclophilins A and C induce dysfunction of pancreatic microendothelial cells, Front. Physiol. DOI: 10.3389/fphys.2022.980232
[35] Costas, C., Louzao, M. C., Raposo-Garcia, S., Vale, C., Vieytes, M. R., and Botana, L. M. (2022) Intestinal secretory mechanisms in Okadaic acid induced diarrhoea, Food and Chem Toxicol. 169, 113449. DOI: 10.1016/j.fct.2022.113449
[36] Raposo-Garcia, S., Castro, D., Lence, E., Estévez, P., Leao, J. M., González-Bello, C., Gago-Martinez, A., Louzao, M. C., Vale, C., and Botana, L. M. (2022) In Silico Simulations and Functional Cell Studies Evidence Similar Potency and Distinct Binding of Pacific and Caribbean Ciguatoxins, Exposure and Health. DOI: 10.1007/s12403-022-00513-0
[37] Alves, C., Silva, J., Pintéus, S., Guedes, R. A., Guedes, R. C., Alvariño, R., Freitas, R., Goettert, M. I., Gaspar, H., Alfonso, A., Alpoím, M. C., Botana, L. M., and Pedrosa, R. (2022) Bromoditerpenes from the Red Seaweed Sphaerococcus coronopifolius as Potential Cytotoxic Agents and Proteasome Inhibitors and Related Mechanisms of Action, Mar. Drugs 20, 652. DOI: 10.3390/md20100652
[38] Raposo-García, S.; Costas, C.; Louzao, M. C.; Vale, C.; Botana, L. M. Synergistic effect of environmental food pollutants: Pesticides and marine biotoxins. Sci. Total Environ. 2022. DOI: 10.1016/j.scitotenv.2022.160111.
[39] Rodríguez-Cañás, I.; González-Jartín, J. M.; Alvariño, R.; Alfonso, A.; Vieytes, M. R.; Botana, L. M. Detection of Mycotoxins in Cheese Using an Optimized Analytical Method Based on a QuEChERS Extraction and UHPLC-MS/MS Quantification. Food Chem. 2022. DOI: 10.1016/j.foodchem.2022.135182.
[40] González-Jartín, J. M.; Alfonso, A.; Botana, L. M.; Vieytes, M. R.; Botana, L. M., Analysis of natural toxins by liquid chromatography. Chapter 7. In Liquid Chromatography, Fanali, S., Ed. Elsevier: 2023. DOI 10.1016/B978-0-323-99969-4.00009-7 Book chapter.
[41] Turner AD, Dean KJ, Dhanji-Rapkova M, Dall'Ara S, Pino F, McVey C, Haughey S, Logan N, Elliott C, Gago-Martinez A, Leao JM, Giraldez J, Gibbs R, Thomas K, Perez-Calderon R, Faulkner D, McEneny H, Savar V, Reveillon D, Hess P, Arevalo F, Lamas JP, Cagide E, Alvarez M, Antelo A, Klijnstra MD, Oplatowska-Stachowiak M, Kleintjens T, Sajic N, Boundy MJ, Maskrey BH, Harwood DT, Jartin JMG, Alfonso A, Botana LM: Interlaboratory evaluation of multiple LC-MS/MS methods and a commercial ELISA method for determination of tetrodotoxin in oysters and mussels. J AOAC Int 2023. DOI: 10.1093/jaoacint/qsad006.
[42] FAO, IOC, IAEA: Joint FAO-IOC-IAEA technical guidance for the implementation of early warning systems for harmful algal blooms. FAO Fisheries and Aquaculture Technical Paper 690. Edited by FAO. Rome: FAO, 2023.
[43] Saldivia P, Hernández M, Isla A, Fritz R, Varela D, González-Jartín JM, Figueroa J, Botana LM, Vargas C, Yañez AJ: Proteomic and toxicological analysis of the response of dinoflagellate Alexandrium catenella to changes in NaNO3 concentration. Harmful Algae 2023, 125:102428. DOI: 10.1016/j.hal.2023.102428.
[44] Gegunde S, Alfonso A, Alvarino R, Perez-Fuentes N, Bayon-Lorenzo J, Alonso E, Ocaranza-Sanchez R, Abellas-Sequeiros RA, Santas-Alvarez M, Vieytes MR, Juanatey-Gonzalez C, Botana LM: Association of cyclophilins and cardiovascular risk factors in coronary artery disease. Front Physiol 2023, 14:1127468. DOI: 10.3389/fphys.2023.1127468
[45] Alvarino R, Gil-Mouce C, Botana MA, Gegunde S, Gonzalez-Jartin J, Vieytes MR, Alfonso A, Botana LM: Cyclophilin B serum levels present variations across the menstrual cycle. Sci Rep 2023, 13:10139. DOI: 10.1038/s41598-023-37322-7
[46] Gegunde S, Alfonso A, Cifuentes JM, Alvarino R, Perez-Fuentes N, Vieytes MR, Botana LM: Cyclophilins modify their profile depending on the organ or tissue in a murine inflammatory model. Int Immunopharmacol 2023, 120:110351. DOI: 10.1016/j.intimp.2023.110351
[47] Rodríguez-Cañas, I.; González-Jartín, J. M.; Alfonso, A.; Alvariño, R.; Vieytes, M. R.; Botana, L. M. Application of a multi-toxin detect method to analyze mycotoxins occurrence in plant-based beverages. Food Chem. 2023, 434, 137427. DOI: 10.1016/j.foodchem.2023.137427.
[48] Habauzit, D.; Alvariño, R.; Pérez-Fuentes, N.; Huet, S.; Alfonso, A.; Hogeveen, K.; Botana, L. M.; Fessard, V. In Vitro Testing of Lung Carcinogenicity for an In Silico-Identified Cluster of Mycotoxins. Exposure and Health 2023. DOI: 10.1007/s12403-023-00601-9.
[49] Pérez-Fuentes, N.; Alvariño, R.; Alfonso, A.; González-Jartín, J. M.; Vieytes, M. R.; Botana, L. M. The Mode of Action of Enniatins A and B is Mediated by Interaction with SOC Reservoirs (A) and Mitochondrial Permeability Transition Pore (B). Exposure and Health 2023. DOI: 10.1007/s12403-023-00613-5.
[50] Raposo-García, S.; Cao, A.; Costas, C.; Louzao, M. C.; Vilariño, N.; Vale, C.; Botana, L. M. Mouse N2a Neuroblastoma Assay: Uncertainties and Comparison with Alternative Cell-Based Assays for Ciguatoxin Detection. Mar. Drugs 2023, 21, 590. DOI: 10.3390/md21110590.
[51] Raposo-Garcia, S.; Costas, C.; Louzao, M. C.; Vieytes, M. R.; Vale, C.; Botana, L. M. Synergistic Effect of Brevetoxin BTX‐3 and Ciguatoxin CTX3C in Human Voltage-Gated Nav1.6 Sodium Channels. Chem Res in Toxicol 2023. DOI: 10.1021/acs.chemrestox.3c00267.
[52] Graña, A.; Carrera, C.; Botana, L. M. Current perspective of vaccination in Spain for dogs and cats from a pharmaceutical approach. Pharm. Pract. (Granada) 2023, 21 (4), 2865. DOI: 10.18549/PharmPract.2023.4.2865.
[53] Raposo-Garcia, S.; Botana, A. M.; Rey, V.; Costas, C.; Rodríguez-Santos, L.; Louzao, M. C.; Vale, C.; Botana, L. M. Analytical and functional profiles of paralytic shellfish toxins extracted from Semele proficua and Senilia senilis from Angola. Heliyon 2024. DOI: 10.1016/j.heliyon.2024.e25338.
[54] Alvariño, R.; Alfonso, A.; Tabudravu, J. N.; González-Jartín, J. M.; Al Maqbali, K. S.; Elhariry, M.; Vieytes, M. R.; Botana, L. M. Psammaplin A and Its Analogs Attenuate Oxidative Stress in Neuronal Cells through Peroxisome Proliferator-Activated Receptor γ Activation. J. Nat. Toxins 2024. DOI: 10.1021/acs.jnatprod.4c00153.
[55] O´Brien, S.; Alvariño, R.; Kennedy, B.; Botana, L. M.; Thomas, O. P., Antioxidant micropeptins from a Microcoleus autumnalis-dominated benthic cyanobacterial mat from Western Ireland. Phytochemistry 2024, 223, 114137. DOI: 10.1016/j.phytochem.2024.114137
[56] González-Jartín, J. M.; Castro-Alves, L.; Piñeiro, Y.; Alfonso, A.; Alvariño, R.; González-Gómez, M.; Vieytes, M. R.; Rivas, J.; Botana, L. M., Magnetic nanostructured agents for the mitigation of mycotoxins and cyanotoxins in the food chain. Food Chem. 2024, 14004. DOI: 10.1016/j.foodchem.2024.140004
[57] Cao, A.; Vilariño, N.; Castro-Alves, L.; Piñeiro, Y.; Rivas, J.; Botana, A. M.; Carrera, C.; Sainz, M. J.; Botana, L. M., Nanostructured Magnetic Particles for Removing Cyanotoxins: Assessing Effectiveness and Toxicity In Vitro. Toxins (Basel) 2024, 16, 269. DOI: 10.3390/toxins16060269
[58] González-Jartín, J. M.; Rodríguez-Cañás, I.; Alvariño, R.; Alfonso, A.; Sainz, M. J.; Vieytes, M. R.; Gomes, A.; Ramos, I.; Botana, L. M., Occurrence of mycotoxins in total mixed ration of dairy farms in Portugal and carry-over to milk. Food Control 2024, 110682. DOI: 10.1016/j.foodcont.2024.110682
[59] Rodriguez-Santos, L.; Costas, C.; Louzao, M. C.; Cagide, E.; Alvarez, M.; Rodriguez-Canas, I.; Raposo-Garcia, S.; Vale, C.; Vieytes, M. R.; Lolo, M.; et al. Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity. Chemosphere 2024, 143419. DOI: 10.1016/j.chemosphere.2024.143419.
[60] Perez-Fuentes, N.; Alvarino, R.; Alfonso, A.; Gonzalez-Jartin, J.; Vieytes, M. R.; Botana, L. M. In vitro assessment of emerging mycotoxins co-occurring in cheese: a potential health hazard. Arch. Toxicol. 2024. DOI: 10.1007/s00204-024-03872-6.
[61] Rodriguez-Canas, I.; Gonzalez-Jartin, J. M.; Alvarino, R.; Alfonso, A.; Vieytes, M. R.; Botana, L. M. Identification of mycotoxins in yogurt samples using an optimized QuEChERS extraction and UHPLC-MS/MS detection. Mycotoxin Res 2024. DOI: 10.1007/s12550-024-00547-0.
[62] Perez-Fuentes, N.; Alvarino, R.; Alfonso, A.; Gonzalez-Jartin, J.; Vieytes, M. R.; Botana, L. M. Enniatins A1 and B1 Modulate Calcium Flux through Alternative Pathways beyond Mitochondria. J. Agric. Food Chem. 2024, 72 (26), 14975-14983. DOI: 10.1021/acs.jafc.4c04242.
[63] Gonzalez-Jartin, J. M.; Aguin, O.; Rodriguez-Canas, I.; Alvarino, R.; Sainz, M. J.; Vieytes, M. R.; Rial, C.; Pinon, P.; Salinero, C.; Alfonso, A.; et al. First description of adenosine production by Gnomoniopsis smithogilvyi, causal agent of chestnut brown rot. World J. Microbiol. Biotechnol. 2024, 40 (5), 148. DOI: 10.1007/s11274-024-03958-4.
2015-2020
[1] Silva, M., Rodriguez, I., Barreiro, A., Kaufmann, M., Neto, A. I., Hassouani, M., Sabour, B., Alfonso, A., Botana, L. M., and Vasconcelos, V. (2020) Lipophilic toxins occurrence in non-traditional invertebrate vectors from North Atlantic Waters (Azores, Madeira, and Morocco): Update on geographical tendencies and new challenges for monitoring routines, Mar. Pollut. Bull. 161, 111725.
[2] Rouco, L., Liberato, A., Fernandez-Trujillo, M. J., Manez, A., Basallote, M. G., Alvarino, R., Alfonso, A., Botana, L. M., and Maneiro, M. (2020) Salenmanganese complexes for controlling ROS damage: Neuroprotective effects, antioxidant activity and kinetic studies, J. Inorg. Biochem. 203, 110918.
[3] Otero, P., Vale, C., Boente-Juncal, A., Costas, C., Louzao, M. C., and Botana, L. M. (2020) Detection of Cyclic Imine Toxins in Dietary Supplements of Green Lipped Mussels (Perna canaliculus) and in Shellfish Mytilus chilensis, Toxins (Basel) 12.
[4] Molgo, J., Schlumberger, S., Sasaki, M., Fuwa, H., Louzao, M. C., Botana, L. M., Servent, D., and Benoit, E. (2020) Gambierol Potently Increases Evoked Quantal Transmitter Release and Reverses Pre- and Post-Synaptic Blockade at Vertebrate Neuromuscular Junctions, Neuroscience 439, 106-116.
[5] Miguel-Gordo, M., Gegunde, S., Jennings, L. K., Genta-Jouve, G., Calabro, K., Alfonso, A., Botana, L. M., and Thomas, O. P. (2020) Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge Stylissa aff. carteri Collected off the Futuna Islands, J. Nat. Prod. 83, 2299-2304.
[6] Gonzalez-Jartin, J. M., de Castro Alves, L., Alfonso, A., Pineiro, Y., Vilar, S. Y., Rodriguez, I., Gomez, M. G., Osorio, Z. V., Sainz, M. J., Vieytes, M. R., Rivas, J., and Botana, L. M. (2020) Magnetic nanostructures for marine and freshwater toxins removal, Chemosphere 256, 127019.
[7] Gegunde, S., Alfonso, A., Alonso, E., Alvarino, R., and Botana, L. M. (2020) Gracilin-Derivatives as Lead Compounds for Anti-inflammatory Effects, Cell. Mol. Neurobiol. 40, 603-615.
[8] Boente-Juncal, A., Vale, C., Camina, M., Cifuentes, J. M., Vieytes, M. R., and Botana, L. M. (2020) Reevaluation of the acute toxicity of palytoxin in mice: Determination of lethal dose 50 (LD50) and No-observed-adverse-effect level (NOAEL), Toxicon 177, 16-24.
[9] Boente-Juncal, A., Raposo-Garcia, S., Vale, C., Louzao, M. C., Otero, P., and Botana, L. M. (2020) In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin, Toxins (Basel) 12.
[10] Boente-Juncal, A., Raposo-Garcia, S., Costas, C., Louzao, M. C., Vale, C., and Botana, L. M. (2020) Partial Blockade of Human Voltage-Dependent Sodium Channels by the Marine Toxins Azaspiracids, Chem. Res. Toxicol. 33, 2593-2604.
[11] Boente-Juncal, A., Otero, P., Rodriguez, I., Camina, M., Rodriguez-Vieytes, M., Vale, C., and Botana, L. M. (2020) Oral Chronic Toxicity of the Safe Tetrodotoxin Dose Proposed by the European Food Safety Authority and Its Additive Effect with Saxitoxin, Toxins (Basel) 12.
[12] Bayon, J., Alfonso, A., Gegunde, S., Alonso, E., Alvarino, R., Santas-Alvarez, M., Testa-Fernandez, A., Rios-Vazquez, R., Botana, L., and Gonzalez-Juanatey, C. (2020) Cyclophilins in Ischemic Heart Disease: Differences Between Acute and Chronic Coronary Artery Disease Patients, Cardiol Res 11, 319-327.
[13] Alves, C., Serrano, E., Silva, J., Rodrigues, C., Pinteus, S., Gaspar, H., Botana, L. M., Alpoim, M. C., and Pedrosa, R. (2020) Sphaerococcus coronopifolius bromoterpenes as potential cancer stem cell-targeting agents, Biomed. Pharmacother. 128, 110275.
[14] Alvarino, R., Alonso, E., Bornancin, L., Bonnard, I., Inguimbert, N., Banaigs, B., and Botana, L. M. (2020) Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells, Mar. Drugs 18.
[15] Alvarino, R., Alonso, E., Alfonso, A., and Botana, L. M. (2020) Neuroprotective Effects of Apple-Derived Drinks in a Mice Model of Inflammation, Mol. Nutr. Food Res. 64, e1901017.
[16] Silva, M., Rodriguez, I., Barreiro, A., Kaufmann, M., Neto, A. I., Hassouani, M., Sabour, B., Alfonso, A., Botana, L. M., and Vasconcelos, V. (2019) Tetrodotoxins Occurrence in Non-Traditional Vectors of the North Atlantic Waters (Portuguese Maritime Territory, and Morocco Coast), Toxins (Basel) 11.
[17] Otero, P., Miguens, N., Rodriguez, I., and Botana, L. M. (2019) LC-MS/MS Analysis of the Emerging Toxin Pinnatoxin-G and High Levels of Esterified OA Group Toxins in Galician Commercial Mussels, Toxins (Basel) 11.
[18] Miguel-Gordo, M., Gegunde, S., Calabro, K., Jennings, L. K., Alfonso, A., Genta-Jouve, G., Vacelet, J., Botana, L. M., and Thomas, O. P. (2019) Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra, Mar. Drugs 17.
[19] Gonzalez-Jartin, J. M., de Castro Alves, L., Alfonso, A., Pineiro, Y., Vilar, S. Y., Gomez, M. G., Osorio, Z. V., Sainz, M. J., Vieytes, M. R., Rivas, J., and Botana, L. M. (2019) Detoxification agents based on magnetic nanostructured particles as a novel strategy for mycotoxin mitigation in food, Food Chem. 294, 60-66.
[20] Gonzalez-Jartin, J. M., Alfonso, A., Sainz, M. J., Vieytes, M. R., Aguin, O., Ferreiroa, V., and Botana, L. M. (2019) First report of Fusarium foetens as a mycotoxin producer, Mycotoxin Res 35, 177-186.
[21] Gonzalez-Jartin, J. M., Alfonso, A., Rodriguez, I., Sainz, M. J., Vieytes, M. R., and Botana, L. M. (2019) A QuEChERS based extraction procedure coupled to UPLC-MS/MS detection for mycotoxins analysis in beer, Food Chem. 275, 703-710.
[22] Gegunde, S., Alfonso, A., Alonso, E., Alvarino, R., and Botana, L. M. (2019) Gracilin-Derivatives as Lead Compounds for Anti-inflammatory Effects, Cell. Mol. Neurobiol.
[23] Botana, L. M., Alonso, E., Sáinz, M. J., Alfonso, A., Botana, A. M., Louzao, C., Vilariño, N., Vale, C., Camiña, M., and Vieytes, M. R. (2019) Toxins | Neurotoxins, In Encyclopedia of Analytical Science, (3rd ed.) (Worsfold, P., Poole, C., Townshend, A., and Miró, M., Eds.), pp 141-147, Elsevier.
[24] Bornancin, L., Alonso, E., Alvariño, R., Inguimbert, N., Bonnard, I., Botana, L. M., and Banaigs, B. (2019) Structure and biological evaluation of new cyclic and acyclic laxaphycin-A type peptides, Bioorg. Med. Chem. 27, 1966-1980.
[25] Boente-Juncal, A., Vale, C., Cifuentes, M., Otero, P., Camiña, M., Vieytes, M. R., and Botana, L. M. (2019) Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity, Toxins (Basel) 11.
[26] Boente-Juncal, A., Alvarez, M., Antelo, A., Rodriguez, I., Calabro, K., Vale, C., Thomas, O. P., and Botana, L. M. (2019) Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus, Toxins (Basel) 11.
[27] Alvariño, R., Alonso, E., Lacret, R., Oves-Costales, D., Genilloud, O., Reyes, F., Alfonso, A., and Botana, L. M. (2019) Caniferolide A, a Macrolide from Streptomyces caniferus, Attenuates Neuroinflammation, Oxidative Stress, Amyloid-Beta, and Tau Pathology in Vitro, Mol Pharmaceutics 16, 1456-1466.
[28] Alvarino, R., Alonso, E., Abbasov, M. E., Chaheine, C. M., Conner, M. L., Romo, D., Alfonso, A., and Botana, L. M. (2019) Gracilin A Derivatives Target Early Events in Alzheimer's Disease: in Vitro Effects on Neuroinflammation and Oxidative Stress, ACS Chem. Neurosci. 10, 4102-4111.
[29] Alfonso, A., Bayon, J., Gegunde, S., Alonso, E., Alvariño, R., Santas-Alvarez, M., Testa-Fernandez, A., Rios-Vazquez, R., Gonzalez-Juanatey, C., and Botana, L. M. (2019) High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease, Sci. Rep. 9, 10576.
[30] Afoullouss, S., Calabro, K., Genta-Jouve, G., Gegunde, S., Alfonso, A., Nesbitt, R., Morrow, C., Alonso, E., Botana, L. M., Allcock, A. L., and Thomas, O. P. (2019) Treasures from the Deep: Characellides as Anti-Inflammatory Lipoglycotripeptides from the Sponge Characella pachastrelloides, Org Lett 21, 246-251.
[31] Abbasov, M. E., Alvarino, R., Chaheine, C. M., Alonso, E., Sanchez, J. A., Conner, M. L., Alfonso, A., Jaspars, M., Botana, L. M., and Romo, D. (2019) Simplified immunosuppressive and neuroprotective agents based on gracilin A, Nat. Chem. 11, 342-350.
[32] Abal, P., Louzao, M. C., Vilariño, N., Vieytes, M. R., and Botana, L. M. (2019) Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin, Toxins (Basel) 11.
[33] Pinteus, S.; Lemos, M. F. L.; Alves, C.; Neugebauer, A.; Silva, J.; Thomas, O. P.; Botana, L. M.; Gaspar, H.; Pedrosa, R. Marine invasive macroalgae: Turning a real threat into a major opportunity - the biotechnological potential of Sargassum muticum and Asparagopsis armata. Algal Research 2018, 34, 217-234. DOI: 10.1016/j.algal.2018.06.018.
[34] Vilarino, N., Louzao, M. C., Abal, P., Cagide, E., Carrera, C., Vieytes, M. R., and Botana, L. M. (2018) Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection, Toxins (Basel) 10.
[35] Van de Waal, D. B., Guillebault, D., Alfonso, A., Rodriguez, I., Botana, L. M., Bijkerk, R., and Medlin, L. K. (2018) Molecular detection of harmful cyanobacteria and expression of their toxin genes in Dutch lakes using multi-probe RNA chips, Harmful Algae 72, 25-35.
[36] Silva, M., Rey, V., Barreiro, A., Kaufmann, M., Neto, A. I., Hassouani, M., Sabour, B., Botana, A., Botana, L. M., and Vasconcelos, V. (2018) Paralytic Shellfish Toxins Occurrence in Non-Traditional Invertebrate Vectors from North Atlantic Waters (Azores, Madeira, and Morocco), Toxins (Basel) 10.
[37] Sainz, M. J., González-Jartín, J. M., Aguín, O., Mansilla, J. P., and Botana, L. M. (2018) Isolation, characterization, and identification of mycotoxin-producing fungi., In Environ. Toxicol. (Botana, L. M., Ed.), pp 202-245, De Gruyter, Berlin.
[38] Rubiolo, J. A., Vale, C., Boente-Juncal, A., Hirama, M., Yamashita, S., Camina, M., Vieytes, M. R., and Botana, L. M. (2018) Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons, Toxins (Basel) 10.
[39] Rubiolo, J. A., Lozano-Leon, A., Rodriguez-Souto, R., Fol Rodriguez, N., Vieytes, M. R., and Botana, L. M. (2018) The impact of depuration on mussel hepatopancreas bacteriome composition and predicted metagenome, Antonie Van Leeuwenhoek 111, 1117-1129.
[40] Rouco, L., Fernández-García, M. I., Pedrido, R., Botana, L. M., Esteban-Gómez, D., Platas-Iglesias, C., and Maneiro, M. (2018) Modeling the OEC with Two New Biomimetic Models: Preparations, Structural Characterization, and Water Photolysis Studies of a Ba–Mn Box Type Complex and a Mn4N6 Planar-Diamond Cluster, Catalysts 8.
[41] Rodriguez, I., Alfonso, A., Gonzalez-Jartin, J. M., Vieytes, M. R., and Botana, L. M. (2018) A single run UPLC-MS/MS method for detection of all EU-regulated marine toxins, Talanta 189, 622-628.
[42] Rey, V., Botana, A. M., Antelo, A., Alvarez, M., and Botana, L. M. (2018) Rapid analysis of paralytic shellfish toxins and tetrodotoxins by liquid chromatography-tandem mass spectrometry using a porous graphitic carbon column, Food Chem. 269, 166-172.
[43] Levert, A., Alvarino, R., Bornancin, L., Abou Mansour, E., Burja, A. M., Geneviere, A. M., Bonnard, I., Alonso, E., Botana, L., and Banaigs, B. (2018) Structures and Activities of Tiahuramides A-C, Cyclic Depsipeptides from a Tahitian Collection of the Marine Cyanobacterium Lyngbya majuscula, J. Nat. Prod. 81, 1301-1310.
[44] Guillen, P. O., Gegunde, S., Jaramillo, K. B., Alfonso, A., Calabro, K., Alonso, E., Rodriguez, J., Botana, L. M., and Thomas, O. P. (2018) Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation, Mar. Drugs 16.
[45] Gonzalez-Jartin, J. M., Alfonso, A., Sainz, M. J., Vieytes, M. R., and Botana, L. M. (2018) Detection of new emerging type-A trichothecenes by untargeted mass spectrometry, Talanta 178, 37-42.
[46] Calabro, K., Genta-Jouve, G., Gegunde, S., Alfonso, A., Nesbitt, R., Morrow, C., Alonso, E., Botana, L. M., Allcock, L., and Thomas, O. P. (2018) Treasures from the Deep: Characellides as Anti-Inflammatory Lipoglycotripeptides from the Sponge Characella pachastrelloides, Org Lett 21, 246-251.
[47] Cabezas-Sainz, P., Guerra-Varela, J., Carreira, M. J., Mariscal, J., Roel, M., Rubiolo, J. A., Sciara, A. A., Abal, M., Botana, L. M., Lopez, R., and Sanchez, L. (2018) Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool, BMC Cancer 18, 3.
[48] Botana, L. M., Alonso, E., Alfonso, A., Romo, D., and Abbasov., M. E. (2018) Gracilin A and congeners as immunosuppressive and neuroprotective agents, p Provissional application.
[49] Botana, L. M. (2018) Una visión de las toxinas marinas en el horizonte del año 2050 desde la perspectiva del cambio climático, la bioseguridad y la seguridad alimentaria., In Trabajo de Futuros. Panorama de tendencias geopolíticas. (Estratégicos, I. E. d. E., Ed.), pp 1-12.
[50] Boente-Juncal, A., Vale, C., Alfonso, A., and Botana, L. M. (2018) Synergistic Effect of Transient Receptor Potential Antagonist and Amiloride against Maitotoxin Induced Calcium Increase and Cytotoxicity in Human Neuronal Stem Cells, ACS Chem. Neurosci. 9, 2667-2678.
[51] Boente-Juncal, A., Mendez, A. G., Vale, C., Vieytes, M. R., and Botana, L. M. (2018) In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development, ACS Chem. Neurosci. 9, 1441-1452.
[52] Alves, C., Silva, J., Pinteus, S., Gaspar, H., Alpoim, M. C., Botana, L. M., and Pedrosa, R. (2018) From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds, Front. Pharmacol. 9, 777.
[53] Alvarino, R., Alonso, E., Lacret, R., Oves-Costales, D., Genilloud, O., Reyes, F., Alfonso, A., and Botana, L. M. (2018) Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro, Neuropharmacology 141, 283-295.
[54] Aguín, O., Ferreiroa, V., González-Jartín, J. M., Alfonso, A., Botana, L. M., Mansilla, J. P., and Sainz, M. J. (2018) Pilidium lythri Is Associated with Bunch Rot of Grapevine (Vitis vinifera), Am J Enol Vitic 69, 410-416.
[55] Abal, P., Louzao, M. C., Suzuki, T., Watanabe, R., Vilariño, N., Carrera, C., Botana, A. M., Vieytes, M. R., and Botana, L. M. (2018) Toxic Action Reevaluation of Okadaic Acid, Dinophysistoxin-1 and Dinophysistoxin-2: Toxicity Equivalency Factors Based on the Oral Toxicity Study, Cell. Physiol. Biochem. 49, 743-757.
[56] Sanchez, J. A., Alfonso, A., Thomas, O. P., and Botana, L. M. (2017) Autumnalamide targeted proteins of the immunophilin family, Immunobiology 222, 241-250.
[57] Rodríguez, I., González, J. M., Botana, A. M., Sáinz, M. J., Vieytes, M. R., Alfonso, A., and Botana, L. M. (2017) Analysis of natural toxins by liquid chromatrography, In Liquid Chromatrography. Applications. (Fanali, S., Haddad, P. R., Poole, C. F., and Riekkola, M. L., Eds.), pp 479-514, Elsevier, Amsterdam.
[58] Rodriguez, I., Fraga, M., Alfonso, A., Guillebault, D., Medlin, L., Baudart, J., Jacob, P., Helmi, K., Meyer, T., Breitenbach, U., Holden, N. M., Boots, B., Spurio, R., Cimarelli, L., Mancini, L., Marcheggiani, S., Albay, M., Akcaalan, R., Koker, L., and Botana, L. M. (2017) Monitoring of freshwater toxins in European environmental waters by using novel multi-detection methods, Environ. Toxicol. Chem. 36, 645-654.
[59] Rodriguez, I., Alfonso, A., Alonso, E., Rubiolo, J. A., Roel, M., Vlamis, A., Katikou, P., Jackson, S. A., Menon, M. L., Dobson, A., and Botana, L. M. (2017) The association of bacterial C9-based TTX-like compounds with Prorocentrum minimum opens new uncertainties about shellfish seafood safety, Sci. Rep. 7, 40880.
[60] Rey, V., Botana, A. M., and Botana, L. M. (2017) Quantification of PSP toxins in toxic shellfish matrices using post-column oxidation liquid chromatography and pre-column oxidation liquid chromatography methods suggests post-column oxidation liquid chromatography as a good monitoring method of choice, Toxicon 129, 28-35.
[61] Mendez, A. G., Juncal, A. B., Silva, S. B. L., Thomas, O. P., Martin Vazquez, V., Alfonso, A., Vieytes, M. R., Vale, C., and Botana, L. M. (2017) The Marine Guanidine Alkaloid Crambescidin 816 Induces Calcium Influx and Cytotoxicity in Primary Cultures of Cortical Neurons through Glutamate Receptors, ACS Chem. Neurosci. 8, 1609-1617.
[62] Knutsen, H., Alexander, J., Barregard, L., Bignami, M., Bruschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L., Nebbia, C., Oswald, I., Rose, M., Roudot, A., Schwerdtle, T., Vleminckx, C., Vollmer, G., Wallace, H., Arnich, N., Benford, D., Botana, L., Viviani, B., Arcella, D., Binaglia, M., Horvath, Z., Steinkellner, H., van Manen, M., and Petersen, A. (2017) Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods. EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain). Scientific Opinion, EFSA Journal 15, 4752-4817.
[63] Gonzalez-Jartin, N. J., Alfonso, A., Sainz, M. J., Vieytes, M. R., and Botana, L. M. (2017) UPLC-MS-IT-TOF Identification of Circumdatins Produced by Aspergillus ochraceus, J. Agric. Food Chem. 65, 4843-4852.
[64] Fraga, M., Vilarino, N., Louzao, M. C., Molina, L., Lopez, Y., Poli, M., and Botana, L. M. (2017) First Identification of Palytoxin-Like Molecules in the Atlantic Coral Species Palythoa canariensis, Anal. Chem. 89, 7438-7446.
[65] Ferreiro, S. F., Vilarino, N., Carrera, C., Louzao, M. C., Santamarina, G., Cantalapiedra, A. G., Cifuentes, J. M., Vieira, A. C., and Botana, L. M. (2017) Subacute immunotoxicity of the marine phycotoxin yessotoxin in rats, Toxicon 129, 74-80.
[66] Ferreiro, S. F., Vilarino, N., Carrera, C., Louzao, M. C., Santamarina, G., Cantalapiedra, A. G., Cifuentes, J. M., Crespo, A., and Botana, L. M. (2017) In vivo cardiomyocyte response to YTX- and AZA-1-induced damage: autophagy versus apoptosis, Arch. Toxicol. 91, 1859-1870.
[67] Botana, L. M., and Vasconcelos, V. (2017) Remembering Dr. Rex Munday, Toxins (Basel) 9.
[68] Botana, L. M., Hess, P., Munday, R., Nathalie, A., DeGrasse, S. L., Feeley, M., Suzuki, T., van den Berg, M., Fattori, V., Garrido Gamarro, E., Tritscher, A., Nakagawa, R., and Karunasagar, I. (2017) Derivation of toxicity equivalency factors for marine biotoxins associated with Bivalve Molluscs, Trends in Food Science & Technology 59, 15-24.
[69] Botana, L. M., Alfonso, A., Vieytes, M. R., Louzao, M. C., Botana, A. M., Vale, C., and Vilariño, N. (2017) Determination of saxitoxin, tetrodotoxin, and common phycotoxins, In Analysis of food toxins and toxicants (Wong, Y. C., and Lewis, R. L., Eds.), pp 431-467, John Wiley & Sons, Hoboken, NJ, USA.
[70] Botana, L. M. (2017) Editorial overview: Food toxicology, Current Opinion in Food Science 18.
[71] Alvarino, R., Alonso, E., Tribalat, M. A., Gegunde, S., Thomas, O. P., and Botana, L. M. (2017) Evaluation of the Protective Effects of Sarains on H2O2-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Neuroblastoma Cells, Neurotox. Res. 32, 368-380.
[72] Alonso, E., Vieira, A. C., Rodriguez, I., Alvarino, R., Gegunde, S., Fuwa, H., Suga, Y., Sasaki, M., Alfonso, A., Cifuentes, J. M., and Botana, L. M. (2017) Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid beta Expression in Mice Brains: Implications in AD Pathology, ACS Chem. Neurosci. 8, 1358-1367.
[73] Abal, P., Louzao, M. C., Fraga, M., Vilarino, N., Ferreiro, S., Vieytes, M. R., and Botana, L. M. (2017) Absorption and Effect of Azaspiracid-1 Over the Human Intestinal Barrier, Cell. Physiol. Biochem. 43, 136-146.
[74] Abal, P., Louzao, M. C., Cifuentes, J. M., Vilarino, N., Rodriguez, I., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2017) Characterization of the dinophysistoxin-2 acute oral toxicity in mice to define the Toxicity Equivalency Factor, Food Chem. Toxicol. 102, 166-175.
[75] Abal, P., Louzao, M. C., Antelo, A., Alvarez, M., Cagide, E., Vilarino, N., Vieytes, M. R., and Botana, L. M. (2017) Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL), Toxins (Basel) 9.
[76] Vieira, A. C., Cifuentes, J. M., Bermudez, R., Ferreiro, S. F., Castro, A. R., and Botana, L. M. (2016) Heart Alterations after Domoic Acid Administration in Rats, Toxins (Basel) 8, 68; doi:10.3390/toxins8030068.
[77] Tobio, A., Alfonso, A., Madera-Salcedo, I., Botana, L. M., and Blank, U. (2016) Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model, PLoS One 11, e0167572.
[78] Sanchez, J. A., Alfonso, A., Rodriguez, I., Alonso, E., Cifuentes, J. M., Bermudez, R., Rateb, M. E., Jaspars, M., Houssen, W. E., Ebel, R., Tabudravu, J., and Botana, L. M. (2016) Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation, Front. Immunol. 7, 452.
[79] Sanchez, J. A., Alfonso, A., Leiros, M., Alonso, E., Rateb, M. E., Jaspars, M., Houssen, W. E., Ebel, R., Tabudravu, J., and Botana, L. M. (2016) Identification of Spongionella compounds as cyclosporine A mimics, Pharmacol. Res. 107, 407-414.
[80] Rubiolo, J. A., Vale, C., Martín, V., Mendez, A. G., Juncal, A. B., Vieytes, M. R., and Botana, L. (2016) Transcriptomic Profiling of Mice Primary Cortical Neurons in Response to Medium Change, Transcriptomics: Open Access 04.
[81] Roel, M., Rubiolo, J. A., Guerra-Varela, J., Silva, S. B., Thomas, O. P., Cabezas-Sainz, P., Sanchez, L., Lopez, R., and Botana, L. M. (2016) Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model, Oncotarget 7, 83071-83087.
[82] Rodriguez, I., Alfonso, C., Alfonso, A., Alonso, E., Calabro, K., Thomas, O., and Botana, L. (2016) Isolation and characterisation of new compounds from Gambierdiscus belizeanus, Planta Med. 81, S1-S381.
[83] Rodriguez, I., Alfonso, A., Antelo, A., Alvarez, M., and Botana, L. M. (2016) Evaluation of the Impact of Mild Steaming and Heat Treatment on the Concentration of Okadaic Acid, Dinophysistoxin-2 and Dinophysistoxin-3 in Mussels, Toxins (Basel) 8, 175; doi:110.3390/toxins8060175.
[84] Rey, V., Botana, A. M., Alvarez, M., Antelo, A., and Botana, L. M. (2016) Liquid Chromatography with a Fluorimetric Detection Method for Analysis of Paralytic Shellfish Toxins and Tetrodotoxin Based on a Porous Graphitic Carbon Column, Toxins (Basel) 8, doi:10.3390/toxins8070196.
[85] Nunez, C., Capelo, J. L., Igrejas, G., Alfonso, A., Botana, L. M., and Lodeiro, C. (2016) An overview of the effective combination therapies for the treatment of breast cancer, Biomaterials 97, 34-50.
[86] Martin, N., Ferreiro, S. F., Alonso-Lopes, E., Prado, S., Barbault, F., Nicolas, M., Lecellier, G., Paetz, C., Gaysinski, M., Thomas, O., Botana, L., and Raharivelomanana, P. (2016) Assessment of Rauvolfia nukuhivensis: from uses to biological ac-tivities and chemodiversity, Planta Med. 81, S1-S381.
[84] Klionsky, D. J., (and 2500 authors), and Zughaier, S. M. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy 12, 1-222.
[88] Gonzalez, J. M., Alfonso, A., Sainz, M. J., and Botana, L. M. (2016) Production and detection of the natural ionophore Beauvericin, Planta Med. 81, S1-S381.
[89] Fraga, M., Vilarino, N., Louzao, M. C., Fernandez, D. A., Poli, M., and Botana, L. M. (2016) Detection of palytoxin-like compounds by a flow cytometry-based immunoassay supported by functional and analytical methods, Anal. Chim. Acta 903, 1-12.
[90] Ferreiro, S. F., Vilarino, N., Carrera, C., Louzao, M. C., Cantalapiedra, A. G., Santamarina, G., Cifuentes, J. M., Vieira, A. C., and Botana, L. M. (2016) Subacute Cardiovascular Toxicity of the Marine Phycotoxin Azaspiracid-1 in Rats, Toxicol. Sci. 151, 104-114.
[91] Ferreiro, S. F., Vilarino, N., Carrera, C., Louzao, M. C., Cantalapiedra, A. G., Santamarina, G., Cifuentes, J. M., Vieira, A. C., and Botana, L. M. (2016) Subacute Cardiotoxicity of Yessotoxin: In Vitro and in Vivo Studies, Chem. Res. Toxicol. 29, 981-990.
[92] Espina, B., Cagide, E., Louzao, M. C., Vilarino, N., Vieytes, M. R., Takeda, Y., Sasaki, M., and Botana, L. M. (2016) Cytotoxicity of goniodomin A and B in non contractile cells, Toxicol. Lett. 250-251, 10-20.
[93] Botana, L. M., Alfonso, A., Rodriguez, I., Botana, A. M., Louzao, M. C., and Vieytes, M. R. (2016) How Safe Is Safe for Marine Toxins Monitoring?, Toxins (Basel) 8.
[94] Botana, L. M. (2016) Toxicological Perspective on Climate Change: Aquatic Toxins, Chem. Res. Toxicol. 29, 619-625.
[95] Botana, L. M. (2016) Modo de acción de los fármacos., In Farmacología Veterinaria. Fundamentos y aplicaciones terapéuticas. (Botana, L. M., Ed.), pp 51-82, Editorial Panamericana, Madrid.
[96] Antelo, A., Rey, V., Álvarez, M., Botana, A. M., and Botana, L. M. (2016) Computational model of adsorption for paralytic shellfish poisoning toxins (PSTs) on graphene surface., In http://sciforum.net/conference/94/paper/3569.
[97] Alvarino, R., Alonso, E., Tribalat, M. A., Thomas, O. P., and Botana, L. M. (2016) Effect of alkaloids isolated from Haliclona sp. against hydrogen peroxide-induced injury in SH-SY5Y human neuroblastoma cells, Planta Med. 81, S1-S381.
[98] Alonso, E., Alvarino, R., Leiros, M., Tabudravu, J. N., Feussner, K., Dam, M. A., Rateb, M. E., Jaspars, M., and Botana, L. M. (2016) Evaluation of the Antioxidant Activity of the Marine Pyrroloiminoquinone Makaluvamines, Mar. Drugs 14.
[99] Alonso, E., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2016) Evaluation of toxicity equivalent factors of paralytic shellfish poisoning toxins in seven human sodium channels types by an automated high throughput electrophysiology system, Arch. Toxicol. 90, 479-488.
[100] Alfonso, A., Vieytes, M. R., and Botana, L. M. (2016) Yessotoxin, a Promising Therapeutic Tool, Mar. Drugs 14.
[101] Abal, P., Louzao, M. C., Fraga, M., Vilarino, N., Ferreiro, S., Vieytes, M. R., and Botana, L. M. (2016) Study of permeability of the marine toxin azaspiracid-1 over in vitro human intestinal model, Planta Med. 81, S1-S381.
2010-2015
[1] Vlamis, A., Katikou, P., Rodriguez, I., Rey, V., Alfonso, A., Papazachariou, A., Zacharaki, T., Botana, A. M., and Botana, L. M. (2015) First Detection of Tetrodotoxin in Greek Shellfish by UPLC-MS/MS Potentially Linked to the Presence of the Dinoflagellate Prorocentrum minimum, Toxins (Basel) 7, 1779-1807.
[2] Vilariño, N., Louzao, M. C., Fraga, M., and Botana, L. M. (2015) From science to policy: dynamic adaptation of legal regulations on aquatic biotoxins, In Climate change and marine and freshwater toxins (Botana, L. M., Louzao, M. C., and Vilariño, N., Eds.) 1st ed., pp 441-482, De Gruyter, Berlin.
[3] Vilariño, N., Louzao, M. C., and Botana, L. M. (2015) From science to policy: dynamic adaptation of legal regulations on aquatic biotoxins, In Climate change and marine and freshwater toxins (Botana, L. M., Louzao, M. C., and Vilariño, N., Eds.), pp 441-482, De Gruyter, Berlin.
[4] Vieira, A. C., Aleman, N., Cifuentes, J. M., Bermudez, R., Pena, M. L., and Botana, L. M. (2015) Brain Pathology in Adult Rats Treated With Domoic Acid, Vet. Pathol. 52, 1077-1086.
[5] Tobio, A., Alfonso, A., and Botana, L. M. (2015) C-kit mutations determine dasatinib mechanism of action in HMC-1 neoplastic mast cells: dasatinib differently regulates PKCdelta translocation in HMC-1(560) and HMC-1(560,816) cell lines, Immunopharmacol. Immunotoxicol. 37, 380-387.
[6] Tobio, A., Alfonso, A., and Botana, L. M. (2015) Cross-talks between c-Kit and PKC isoforms in HMC-1(560) and HMC-1(560,816) cells. Different role of PKCdelta in each cellular line, Cell. Immunol. 293, 104-112.
[7] Silva, M., Rodriguez, I., Barreiro, A., Kaufmann, M., Isabel Neto, A., Hassouani, M., Sabour, B., Alfonso, A., Botana, L. M., and Vasconcelos, V. (2015) New Invertebrate Vectors of Okadaic Acid from the North Atlantic Waters--Portugal (Azores and Madeira) and Morocco, Toxins (Basel) 7, 5337-5347.
[8] Silva, M., Rodriguez, I., Barreiro, A., Kaufmann, M., Isabel Neto, A., Hassouani, M., Sabour, B., Alfonso, A., Botana, L. M., and Vasconcelos, V. (2015) First Report of Ciguatoxins in Two Starfish Species: Ophidiaster ophidianus and Marthasterias glacialis, Toxins (Basel) 7, 3740-3757.
[9] Silva, M., Rey, V., Botana, A., Vasconcelos, V., and Botana, L. (2015) Determination of Gonyautoxin-4 in Echinoderms and Gastropod Matrices by Conversion to Neosaxitoxin Using 2-Mercaptoethanol and Post-Column Oxidation Liquid Chromatography with Fluorescence Detection, Toxins (Basel) 8, 11; doi:10.3390/toxins8010011.
[10] Silva, M., Pratheepa, V. K., Botana, L. M., and Vasconcelos, V. (2015) Emergent toxins in North Atlantic temperate waters: a challenge for monitoring programs and legislation, Toxins (Basel) 7, 859-885.
[11] Sanchez, J. A., Alfonso, A., Leiros, M., Alonso, E., Rateb, M. E., Jaspars, M., Houssen, W. E., Ebel, R., and Botana, L. M. (2015) Spongionella Secondary Metabolites Regulate Store Operated Calcium Entry Modulating Mitochondrial Functioning in SH-SY5Y Neuroblastoma Cells, Cell. Physiol. Biochem. 37, 779-792.
[12] Sainz, M. J., Alfonso, A., and Botana, L. M. (2015) Considerations about international mycotoxin legislation, food security, and climate change, In Climate change and mycotoxins (Botana, L. M., and Sainz, M. J., Eds.), pp 153-173, De Gruyter, Berlin.
[13] Rubiolo, J. A., Vale, C., Martin, V., Fuwa, H., Sasaki, M., and Botana, L. M. (2015) Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation, Arch. Toxicol. 89, 1119-1134.
[14] Roel, M., Rubiolo, J. A., Ternon, E., Thomas, O. P., Vieytes, M. R., and Botana, L. M. (2015) Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction, Mar. Drugs 13, 4633-4653.
[15] Rodriguez, I., Genta-Jouve, G., Alfonso, C., Calabro, K., Alonso, E., Sanchez, J. A., Alfonso, A., Thomas, O. P., and Botana, L. M. (2015) Gambierone, a Ladder-Shaped Polyether from the Dinoflagellate Gambierdiscus belizeanus, Org Lett 17, 2392-2395.
[16] Rey, V., Alfonso, A., Botana, L. M., and Botana, A. M. (2015) Influence of different shellfish matrices on the separation of PSP toxins using a postcolumn oxidation liquid chromatography method, Toxins (Basel) 7, 1324-1340.
[17] Martin, V., Vale, C., Rubiolo, J. A., Roel, M., Hirama, M., Yamashita, S., Vieytes, M. R., and Botana, L. M. (2015) Chronic ciguatoxin treatment induces synaptic scaling through voltage gated sodium channels in cortical neurons, Chem. Res. Toxicol. 28, 1109-1119.
[18] Martin, V., Vale, C., Hirama, M., Yamashita, S., Rubiolo, J. A., Vieytes, M. R., and Botana, L. M. (2015) Synthetic ciguatoxin CTX 3C induces a rapid imbalance in neuronal excitability, Chem. Res. Toxicol. 28, 1095-1108.
[19] Martin, N. J., Ferreiro, S. F., Barbault, F., Nicolas, M., Lecellier, G., Paetz, C., Gaysinski, M., Alonso, E., Thomas, O. P., Botana, L. M., and Raharivelomanana, P. (2015) Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels, Phytochemistry 109, 84-95.
[20] Louzao, M. C., Vilariño, N., and Botana, L. M. (2015) Effects on world food production and security, In Climate change and marine and freshwater toxins (Botana, L. M., Louzao, M. C., and Vilariño, N., Eds.) 1st ed., pp 417-440, De Gruyter, Berlin.
[21] Louzao, M. C., Fernandez, D. A., Abal, P., Fraga, M., Vilarino, N., Vieytes, M. R., and Botana, L. M. (2015) Diarrhetic effect of okadaic acid could be related with its neuronal action: Changes in neuropeptide Y, Toxicol. Lett. 237, 151-160.
[22] Louzao, M. C., Abal, P., Fernandez, D. A., Vieytes, M. R., Legido, J. L., Gomez, C. P., Pais, J., and Botana, L. M. (2015) Study of Adsorption and Flocculation Properties of Natural Clays to Remove Prorocentrum lima, Toxins (Basel) 7, 3977-3988.
[23] Leiros, M., Alonso, E., Rateb, M. E., Houssen, W. E., Ebel, R., Jaspars, M., Alfonso, A., and Botana, L. M. (2015) Gracilins: Spongionella-derived promising compounds for Alzheimer disease, Neuropharmacology 93, 285-293.
[24] Leiros, M., Alonso, E., Rateb, M. E., Houssen, W. E., Ebel, R., Jaspars, M., Alfonso, A., and Botana, L. M. (2015) Bromoalkaloids protect primary cortical neurons from induced oxidative stress, ACS Chem. Neurosci. 6, 331-338.
[25] Leiros, M., Alonso, E., Rateb, M. E., Ebel, R., Jaspars, M., Alfonso, A., and Botana, L. M. (2015) The Streptomyces metabolite anhydroexfoliamycin ameliorates hallmarks of Alzheimer's disease in vitro and in vivo, Neuroscience 305, 26-35.
[26] Ferreiro, S. F., Carrera, C., Vilarino, N., Louzao, M. C., Santamarina, G., Cantalapiedra, A. G., and Botana, L. M. (2015) Acute cardiotoxicity evaluation of the marine biotoxins OA, DTX-1 and YTX, Toxins (Basel) 7, 1030-1047.
[27] Fernandez-Araujo, A., Sanchez, J. A., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2015) Different toxic effects of YTX in tumor K-562 and lymphoblastoid cell lines, Front. Pharmacol. 6, 124.
[28] Fernandez-Araujo, A., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2015) Key role of phosphodiesterase 4A (PDE4A) in autophagy triggered by yessotoxin, Toxicology 329, 60-72.
[29] Fernandez-Araujo, A., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2015) Yessotoxin activates cell death pathways independent of Protein Kinase C in K-562 human leukemic cell line, Toxicol. In Vitro 29, 1545-1554.
[30] Crespo, A., Cifuentes, J. M., Bermúdez, R., Antelo, A., Alemañ, N., and Botana, L. M. (2015) Dose-response and histopathological study, with special attention to the hypophysis, of the differential effects of domoic acid on rats and mice, Microsc. Res. Tech. 78, 396-403.
[31] Chevallier, O. P., Graham, S. F., Alonso, E., Duffy, C., Silke, J., Campbell, K., Botana, L. M., and Elliott, C. T. (2015) New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish, Sci. Rep. 5, 9818.
[32] Botana, L. M., and Sainz, M. J., (Eds.) (2015) Climate change and mycotoxins, De Gruyter, Berlin.
[33] Botana, L. M., Louzao, M. C., and Vilariño, N., (Eds.) (2015) Climate change and marine and freshwater toxins, 1st ed., De Gruyter, Berlin.
[34] Botana, L. M., and Alfonso, A. (2015) Phycotoxins. Chemistry and Biochemistry, Wiley Blackwell, Oxford.
[35] Botana, A. M., and Rey, V. (2015) Chemistry and analysis of PSP toxins, In Phycotoxins. Chemistry and Biochemistry (Botana, L. M., and Alfonso, A., Eds.) 3rd edition ed., pp 69-84, John Wiley and Sons, Oxford.
[36] Tobio, A., Alfonso, A., and Botana, L. M. (2014) PKC potentiates tyrosine kinase inhibitors STI571 and dasatinib cytotoxic effect, Anticancer Res. 34, 3347-3356.
[37] Sanchez, J. A., Otero, P., Alfonso, A., Ramos, V., Vasconcelos, V., Araoz, R., Molgo, J., Vieytes, M. R., and Botana, L. M. (2014) Detection of anatoxin-a and three analogs in Anabaena spp. cultures: new fluorescence polarization assay and toxin profile by LC-MS/MS, Toxins (Basel) 6, 402-415.
[38] Rubiolo, J. A., Lopez-Alonso, H., Roel, M., Vieytes, M. R., Thomas, O., Ternon, E., Vega, F. V., and Botana, L. M. (2014) Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells, Br. J. Pharmacol. 171, 1655-1667.
[39] Rubiolo, J. A., Lopez-Alonso, H., Martinez, P., Millan, A., Cagide, E., Vieytes, M. R., Vega, F. V., and Botana, L. M. (2014) Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3, Cell. Signal. 26, 419-432.
[40] Rodriguez, L. P., Vilarino, N., Louzao, M. C., Dickerson, T. J., Nicolaou, K. C., Frederick, M. O., and Botana, L. M. (2014) Microsphere-based immunoassay for the detection of azaspiracids, Anal. Biochem. 447, 58-63.
[41] Rodriguez, I., Rodriguez, C., Alfonso, A., Otero, P., Meyer, T., Breitenbach, U., and Botana, L. M. (2014) Toxin profile in samples collected in fresh and brackish water in Germany, Toxicon 91, 35-44.
[42] Martin, V., Vale, C., Antelo, A., Hirama, M., Yamashita, S., Vieytes, M. R., and Botana, L. M. (2014) Differential effects of ciguatoxin and maitotoxin in primary cultures of cortical neurons, Chem. Res. Toxicol. 27, 1387-1400.
[43] María, F. C., Natalia, V., M. Carmen, L., and Luis M, B. (2014) Sensitivity improvement of an immuno-detection method for azaspiracids based on the use of microspheres coupled to a flow-fluorimetry system, Frontiers in Marine Science 1.
[44] Leiros, M., Sanchez, J. A., Alonso, E., Rateb, M. E., Houssen, W. E., Ebel, R., Jaspars, M., Alfonso, A., and Botana, L. M. (2014) Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress, Mar. Drugs 12, 700-718.
[45] Leiros, M., Alonso, E., Sanchez, J. A., Rateb, M. E., Ebel, R., Houssen, W. E., Jaspars, M., Alfonso, A., and Botana, L. M. (2014) Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons, ACS Chem. Neurosci. 5, 71-80.
[46] Fraga, M., Vilarino, N., Louzao, M. C., Rodriguez, L. P., Alfonso, A., Campbell, K., Elliott, C. T., Taylor, P., Ramos, V., Vasconcelos, V., and Botana, L. M. (2014) Multi-detection method for five common microalgal toxins based on the use of microspheres coupled to a flow-cytometry system, Anal. Chim. Acta 850, 57-64.
[47] Ferreiro, S. F., Vilarino, N., Louzao, M. C., Nicolaou, K. C., Frederick, M. O., and Botana, L. M. (2014) In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2, Toxicon 91, 69-75.
[48] Ferreiro, S. F., Vilarino, N., Carrera, C., Louzao, M. C., Santamarina, G., Cantalapiedra, A. G., Rodriguez, L. P., Cifuentes, J. M., Vieira, A. C., Nicolaou, K. C., Frederick, M. O., and Botana, L. M. (2014) In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats, Arch. Toxicol. 88, 425-434.
[49] Fernandez-Araujo, A., Tobio, A., Alfonso, A., and Botana, L. M. (2014) Role of AKAP 149-PKA-PDE4A complex in cell survival and cell differentiation processes, Int. J. Biochem. Cell Biol. 53, 89-101.
[50] Fernandez, D. A., Louzao, M. C., Vilarino, N., Fraga, M., Espina, B., Vieytes, M. R., and Botana, L. M. (2014) Evaluation of the intestinal permeability and cytotoxic effects of cylindrospermopsin, Toxicon 91, 23-34.
[51] Fernandez, D. A., Louzao, M. C., Fraga, M., Vilarino, N., Vieytes, M. R., and Botana, L. M. (2014) Experimental basis for the high oral toxicity of dinophysistoxin 1: a comparative study of DSP, Toxins (Basel) 6, 211-228.
[52] Campbell, K., McNamee, S. E., Huet, A. C., Delahaut, P., Vilarino, N., Botana, L. M., Poli, M., and Elliott, C. T. (2014) Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish, Anal. Bioanal. Chem. 406, 6867-6881.
[53] Cagide, E., Becher, P. G., Louzao, M. C., Espina, B., Vieytes, M. R., Juttner, F., and Botana, L. M. (2014) Hapalindoles from the cyanobacterium fischerella: potential sodium channel modulators, Chem. Res. Toxicol. 27, 1696-1706.
[54] Botana, L. M., Alfonso, A., Vieytes, M. R., Vilariño, N., Botana, A. M., and Louzao, M. C. (2014) Marine toxins analysis, In Handbook of Water Analysis. (Nollet, L., and De Gelder, L. S. P., Eds.) 3rd ed., pp 153-162, CRC Press, London.
[55] Botana, L. M., Alfonso, A., Vale, C., Vilariño, N., Rubiolo, J., Alonso, E., and Cagide, E. (2014) The mechanistic complexities of phycotoxins: toxicology of azaspiracids and yessotoxins, In Advances in Molecular Toxicology (Fishbein, J. C., and Heiman, J. M., Eds.) First edition ed., pp 1-33, Elsevier, Oxford.
[56] Botana, L. M. (2014) Guide to phycotoxin monitoring of bivalve mollusk-harversting areas, In Seafood and Freshwater toxins: Pharmacology, Physiology and Detection (Botana, L. M., Ed.) 3rd edition ed., pp 39-56, CRC Press (Taylor and Francys Group), Boca Raton, FL.
[57] Barreiro-Costa, O., Tobio, A., Alfonso, A., and Botana, L. M. (2014) Different role of cAMP pathway on the human mast cells HMC-1(560) and HMC-1(560,816) activation, J. Cell. Biochem. 115, 896-909.
[58] Audoin, C., Sanchez, J. A., Genta-Jouve, G., Alfonso, A., Rios, L., Vale, C., Thomas, O. P., and Botana, L. M. (2014) Autumnalamide, a prenylated cyclic peptide from the cyanobacterium Phormidium autumnale, acts on SH-SY5Y cells at the mitochondrial level, Vol. 77.
[59] Vilarino, N., Louzao, M. C., Fraga, M., Rodriguez, L. P., and Botana, L. M. (2013) Innovative detection methods for aquatic algal toxins and their presence in the food chain, Anal. Bioanal. Chem. 405, 7719-7732.
[60] Vieira, A. C., Rubiolo, J. A., Lopez-Alonso, H., Cifuentes, J. M., Alfonso, A., Bermudez, R., Otero, P., Vieytes, M. R., Vega, F. V., and Botana, L. M. (2013) Oral toxicity of okadaic acid in mice: study of lethality, organ damage, distribution and effects on detoxifying gene expression, Toxins (Basel) 5, 2093-2108.
[61] Tobio, A., Alfonso, A., Fernandez-Araujo, A., Alonso, E., and Botana, L. M. (2013) Protein kinase C modulates Aurora-kinase inhibition induced by CCT129202 in HMC-1(5)(6)(0),(8)(1)(6) cell line, Antiinflamm. Antiallergy Agents Med. Chem. 12, 265-276.
[62] Silva, M., Barreiro, A., Rodriguez, P., Otero, P., Azevedo, J., Alfonso, A., Botana, L. M., and Vasconcelos, V. (2013) New invertebrate vectors for PST, spirolides and okadaic acid in the North Atlantic, Mar. Drugs 11, 1936-1960.
[63] Rubiolo, J. A., Ternon, E., Lopez-Alonso, H., Thomas, O. P., Vega, F. V., Vieytes, M. R., and Botana, L. M. (2013) Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae, Mar. Drugs 11, 4419-4434.
[64] Rubiolo, J. A., Lopez-Alonso, H., Alfonso, A., Vega, F. V., Vieytes, M. R., and Botana, L. M. (2013) Bioengineered protein phosphatase 2A: update on need, Bioengineered 4, 72-77.
[65] Rodriguez, L. P., Vilarino, N., Molgo, J., Araoz, R., Louzao, M. C., Taylor, P., Talley, T., and Botana, L. M. (2013) Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system, Anal. Chem. 85, 2340-2347.
[66] Rodriguez, L. P., Vilarino, N., Molgo, J., Araoz, R., and Botana, L. M. (2013) High-throughput receptor-based assay for the detection of spirolides by chemiluminescence, Toxicon 75, 35-43.
[67] Otero, P., Rodríguez, P., Botana, A. M., Alfonso, A., and Botana, L. M. (2013) Analysis of Natural Toxins, In Liquid Chromatography, pp 411-430.
[68] Murray, P. M., Moane, S., Collins, C., Beletskaya, T., Thomas, O. P., Duarte, A. W., Nobre, F. S., Owoyemi, I. O., Pagnocca, F. C., Sette, L. D., McHugh, E., Causse, E., Perez-Lopez, P., Feijoo, G., Moreira, M. T., Rubiolo, J., Leiros, M., Botana, L. M., Pinteus, S., Alves, C., Horta, A., Pedrosa, R., Jeffryes, C., Agathos, S. N., Allewaert, C., Verween, A., Vyverman, W., Laptev, I., Sineoky, S., Bisio, A., Manconi, R., Ledda, F., Marchi, M., Pronzato, R., and Walsh, D. J. (2013) Sustainable production of biologically active molecules of marine based origin, N. Biotechnol. 30, 839-850.
[69] Martin, V., Vale, C., Bondu, S., Thomas, O. P., Vieytes, M. R., and Botana, L. M. (2013) Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons, Chem. Res. Toxicol. 26, 169-178.
[70] Lopez-Alonso, H., Rubiolo, J. A., Vega, F., Vieytes, M. R., and Botana, L. M. (2013) Protein synthesis inhibition and oxidative stress induced by cylindrospermopsin elicit apoptosis in primary rat hepatocytes, Chem. Res. Toxicol. 26, 203-212.
[71] Fraga, M., Vilarino, N., Louzao, M. C., Rodriguez, P., Campbell, K., Elliott, C. T., and Botana, L. M. (2013) Multidetection of paralytic, diarrheic, and amnesic shellfish toxins by an inhibition immunoassay using a microsphere-flow cytometry system, Anal. Chem. 85, 7794-7802.
[72] Fernández-Araujo, A., Alfonso, A., Antelo, J. M., Davila, T., Alfonso, C., Katikou, P., and Botana, L. M. (2013) Warm seawater microalgae: growth and toxic profile of Ostreopsis spp. from european coasts, Journal of Oceanography and Marine Research 1, 104.
[73] Fernandez, D. A., Louzao, M. C., Vilarino, N., Espina, B., Fraga, M., Vieytes, M. R., Roman, A., Poli, M., and Botana, L. M. (2013) The kinetic, mechanistic and cytomorphological effects of palytoxin in human intestinal cells (Caco-2) explain its lower-than-parenteral oral toxicity, FEBS J 280, 3906-3919.
[74] Daneshian, M., Botana, L. M., Dechraoui Bottein, M. Y., Buckland, G., Campas, M., Dennison, N., Dickey, R. W., Diogene, J., Fessard, V., Hartung, T., Humpage, A., Leist, M., Molgo, J., Quilliam, M. A., Rovida, C., Suarez-Isla, B. A., Tubaro, A., Wagner, K., Zoller, O., and Dietrich, D. (2013) A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems, ALTEX 30, 487-545.
[75] Botana, A. M., Otero, P., Rodríguez, P., Alfonso, A., and Botana, L. M. (2013) Current situation on analysis of marine toxins, Reviews in Analytical Chemistry 32.
[76] Alonso, E., Vale, C., Vieytes, M. R., and Botana, L. M. (2013) Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and beta-amyloid pathology, ACS Chem. Neurosci. 4, 1062-1070.
[77] Alonso, E., Otero, P., Vale, C., Alfonso, A., Antelo, A., Gimenez-Llort, L., Chabaud, L., Guillou, C., and Botana, L. M. (2013) Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement, Curr Alzheimer Res 10, 279-289.
[78] Alfonso A, B. L. M. (2013) Warm Seawater Microalgae: Growth and Toxic Profile of Ostreopsis Spp. from European Coasts, Oceanography: Open Access 01.
[79] Alfonso, A., Pazos, M. J., Fernandez-Araujo, A., Tobio, A., Alfonso, C., Vieytes, M. R., and Botana, L. M. (2013) Surface plasmon resonance biosensor method for palytoxin detection based on Na+,K+-ATPase affinity, Toxins (Basel) 6, 96-107.
[80] Tobio, A., Fernandez-Araujo, A., Alfonso, A., and Botana, L. M. (2012) Role of yessotoxin in calcium and cAMP-crosstalks in primary and K-562 human lymphocytes: the effect is mediated by anchor kinase A mitochondrial proteins, J. Cell. Biochem. 113, 3752-3761.
[81] Silva, M., Azevedo, J., Rodriguez, P., Alfonso, A., Botana, L. M., and Vasconcelos, V. (2012) New gastropod vectors and tetrodotoxin potential expansion in temperate waters of the Atlantic Ocean, Mar. Drugs 10, 712-726.
[82] Rubiolo, J. A., Lopez-Alonso, H., Vega, F. V., Vieytes, M. R., and Botana, L. M. (2012) Comparative study of toxicological and cell cycle effects of okadaic acid and dinophysistoxin-2 in primary rat hepatocytes, Life Sci. 90, 416-423.
[83] Rubiolo, J. A., Lopez-Alonso, H., Martin-Vazquez, V., Fol-Rodriguez, N. M., Vieytes, M. R., Botana, L. M., and Vega, F. V. (2012) Resveratrol inhibits proliferation of primary rat hepatocytes in G0/G1 by inhibiting DNA synthesis, Folia Biol. (Praha) 58, 166-172.
[84] Rubiolo, J. A., Lopez-Alonso, H., Alfonso, A., Vega, F. V., Vieytes, M. R., and Botana, L. M. (2012) Characterization and activity determination of the human protein phosphatase 2A catalytic subunit alpha expressed in insect larvae, Appl. Biochem. Biotechnol. 167, 918-928.
[85] Rubiolo, J. A., Botana, L. M., and López, H. (2012) Use of yessotoxin and its derivatives for the treatment of gliomas, In Patent (Compostela, U. o. S. d., Ed.), Spain.
[86] Rodríguez, P., Alfonso, A., Otero, P., Katikou, P., Georgantelis, D., and Botana, L. M. (2012) Liquid chromatography–mass spectrometry method to detect Tetrodotoxin and Its analogues in the puffer fish Lagocephalus sceleratus (Gmelin, 1789) from European waters, Food Chem. 132, 1103-1111.
[87] Perez, S., Vale, C., Alonso, E., Fuwa, H., Sasaki, M., Konno, Y., Goto, T., Suga, Y., Vieytes, M. R., and Botana, L. M. (2012) Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study, Chem. Res. Toxicol. 25, 1929-1937.
[88] Otero, P., Alfonso, A., Rodriguez, P., Rubiolo, J. A., Cifuentes, J. M., Bermudez, R., Vieytes, M. R., and Botana, L. M. (2012) Pharmacokinetic and toxicological data of spirolides after oral and intraperitoneal administration, Food Chem. Toxicol. 50, 232-237.
[89] Otero, P., Alfonso, A., Alfonso, C., Rodríguez, P., Vieytes, M. R., and Botana, L. M. (2012) Response to Comments on “Effect of Uncontrolled Factors in a Validated Liquid Chromatography–Tandem Mass Spectrometry Method Question Its Use as a Reference Method for Marine Toxins: Major Causes for Concern”, Anal. Chem. 84, 481-483.
[90] Fraga, M., Vilarino, N., Louzao, M. C., Campbell, K., Elliott, C. T., Kawatsu, K., Vieytes, M. R., and Botana, L. M. (2012) Detection of paralytic shellfish toxins by a solid-phase inhibition immunoassay using a microsphere-flow cytometry system, Anal. Chem. 84, 4350-4356.
[91] Botana, L. M., Vilariño, N., Alfonso, A., Louzao, M. C., Vieytes, M. R., Botana, A. M., and Vale, C. (2012) Use of Biosensors as alternatives to current regulatory methods for marine biotoxins., In Molecular Biological Technologies for Ocean Sensing (Tiquia-Arashiro, S. M., Ed.), pp 219-242, Humana Press, Springer Protocols, New York.
[92] Botana, L. M., Vieytes, M. R., Botana, A. M., Vale, C., and Vilariño, N. (2012) Biological methods for detection of phycotoxins: bioassays and in vitro assays., In New trends in marine and freshwater toxins (Cabado, A. G., and Vieites, J. M., Eds.), pp 203-214, Nova Science Publishers, Inc., New York.
[93] Botana, L. M., and Loza, M. I., (Eds.) (2012) Therapeutic Targets: Modulation, Inhibition and Activation., John Wiley & Sons, New York.
[94] Botana, L. M., Alonso, E., Vale, C., Fuwa, H., and Sasaki, M. (2012) Cyclic polyethers for treating and/or preventing Tau-and Beta-amyloid linded neurodegenerative diseases, Patent PCT/ES2011/070515, WO 2012/007627 A007621.
[95] Botana, L. M. (2012) A perspective on the toxicology of marine toxins, Chem. Res. Toxicol. 25, 1800-1804.
[96] Bondu, S., Genta-Jouve, G., Leirós, M., Vale, C., Guigonis, J. M., Botana, L. M., and Thomas, O. P. (2012) Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe, RSC Advances 2, 2828-2835.
[97] Araoz, R., Ramos, S., Pelissier, F., Guerineau, V., Benoit, E., Vilarino, N., Botana, L. M., Zakarian, A., and Molgo, J. (2012) Coupling the Torpedo microplate-receptor binding assay with mass spectrometry to detect cyclic imine neurotoxins, Anal. Chem. 84, 10445-10453.
[98] Alonso, E., Fuwa, H., Vale, C., Suga, Y., Goto, T., Konno, Y., Sasaki, M., LaFerla, F. M., Vieytes, M. R., Gimenez-Llort, L., and Botana, L. M. (2012) Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-beta and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications, J. Am. Chem. Soc. 134, 7467-7479.
[99] Alfonso, A., Fernandez-Araujo, A., Alfonso, C., Carames, B., Tobio, A., Louzao, M. C., Vieytes, M. R., and Botana, L. M. (2012) Palytoxin detection and quantification using the fluorescence polarization technique, Anal. Biochem. 424, 64-70.
[100] van den Top, H. J., Elliott, C. T., Haughey, S. A., Vilarino, N., van Egmond, H. P., Botana, L. M., and Campbell, K. (2011) Surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins: a pilot interlaboratory study, Anal. Chem. 83, 4206-4213.
[101] Tobio, A., Alfonso, A., and Botana, L. M. (2011) C-kit mutations and PKC crosstalks: PKC translocates to nucleous only in cells HMC(5)(6)(0),(8)(1)(6), J. Cell. Biochem. 112, 2637-2651.
[102] Rubiolo, J. A., Lopez-Alonso, H., Vega, F. V., Vieytes, M. R., and Botana, L. M. (2011) Okadaic acid and dinophysis toxin 2 have differential toxicological effects in hepatic cell lines inducing cell cycle arrest, at G0/G1 or G2/M with aberrant mitosis depending on the cell line, Arch. Toxicol. 85, 1541-1550.
[103] Rubiolo, J. A., Botana, L. M., and López, H. (2011) Use of yessotoxin and its derivatives for the treatment and/or prevention of metabolic diseases, Patent, PCT/ES2010/070634.
[104] Rodríguez, P., Alfonso, A., Turrell, E., Lacaze, J.-P., and Botana, L. M. (2011) Study of solid phase adsorption of paralytic shellfish poisoning toxins (PSP) onto different resins, Harmful Algae 10, 447-455.
[105] Rodriguez, L. P., Vilarino, N., Molgo, J., Araoz, R., Antelo, A., Vieytes, M. R., and Botana, L. M. (2011) Solid-phase receptor-based assay for the detection of cyclic imines by chemiluminescence, fluorescence, or colorimetry, Anal. Chem. 83, 5857-5863.
[106] Perez, S., Vale, C., Botana, A. M., Alonso, E., Vieytes, M. R., and Botana, L. M. (2011) Determination of toxicity equivalent factors for paralytic shellfish toxins by electrophysiological measurements in cultured neurons, Chem. Res. Toxicol. 24, 1153-1157.
[107] Perez, S., Vale, C., Alonso, E., Alfonso, C., Rodriguez, P., Otero, P., Alfonso, A., Vale, P., Hirama, M., Vieytes, M. R., and Botana, L. M. (2011) A comparative study of the effect of ciguatoxins on voltage-dependent Na+ and K+ channels in cerebellar neurons, Chem. Res. Toxicol. 24, 587-596.
[108] Otero, P., Alfonso, A., Alfonso, C., Rodriguez, P., Vieytes, M. R., and Botana, L. M. (2011) Effect of uncontrolled factors in a validated liquid chromatography-tandem mass spectrometry method question its use as a reference method for marine toxins: major causes for concern, Anal. Chem. 83, 5903-5911.
[109] Otero, P., Alfonso, A., Alfonso, C., Araoz, R., Molgo, J., Vieytes, M. R., and Botana, L. M. (2011) First direct fluorescence polarization assay for the detection and quantification of spirolides in mussel samples, Anal. Chim. Acta 701, 200-208.
[110] Nzoughet, J. K., Grant, I. R., Prodohl, P. A., Hamilton, J. T., Botana, L. M., and Elliott, C. T. (2011) Evidence of Methylobacterium spp. and Hyphomicrobium sp. in azaspiracid toxin contaminated mussel tissues and assessment of the effect of azaspiracid on their growth, Toxicon 58, 619-622.
[111] Louzao, M. C., Ares, I. R., Cagide, E., Espina, B., Vilarino, N., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2011) Palytoxins and cytoskeleton: An overview, Toxicon 57, 460-469.
[112] Espina, B., Otero, P., Louzao, M. C., Alfonso, A., and Botana, L. M. (2011) 13-Desmethyl spirolide-c and 13,19-didesmethyl spirolide-c trans-epithelial permeabilities: human intestinal permeability modelling, Toxicology 287, 69-75.
[113] Espina, B., Louzao, M. C., Ares, I. R., Fonfria, E. S., Vilarino, N., Vieytes, M. R., and Botana, L. M. (2011) Disruption of the actin cytoskeleton induces fluorescent glucose accumulation on the rat hepatocytes Clone 9, Cell. Physiol. Biochem. 27, 653-660.
[114] Campbell, K., Vilariño, N., Botana, L. M., and Elliott, C. T. (2011) A European perspective on progress in moving away from the mouse bioassay for marine-toxin analysis, TrAC Trends in Analytical Chemistry 30, 239-253.
[115] Cagide, E., Louzao, M. C., Espina, B., Ares, I. R., Vieytes, M. R., Sasaki, M., Fuwa, H., Tsukano, C., Konno, Y., Yotsu-Yamashita, M., Paquette, L. A., Yasumoto, T., and Botana, L. M. (2011) Comparative cytotoxicity of gambierol versus other marine neurotoxins, Chem. Res. Toxicol. 24, 835-842.
[116] Botana, L. M., Louzao, M. C., Alfonso, A., Botana, A. M., Vieytes, M. R., Vilariño, N., and Vale, C., (Eds.) (2011) Measurement of Algal Toxins in the Environment, Vol. Environment: Water and Waste, John Willey & Sons Ltd, Chichester.
[117] Botana, L. M., Alonso, E., Vale, C., Fuwa, H., and Sasaki, M. (2011) Use of a spirolide, analogues and derivatives for treating and/or preventing pathological conditions linked to the tau and beta-amyloid proteins, Patent PCT/ES2010/070633, WO 2011/048245 A048241.
[118] Botana, L. M., Alonso, E., and Vale, C. (2011) Use of yessotoxin and analogs and derivatives thereof for treating and/or preventing neurodegenerative diseases linked to tau and beta amyloid, Patent PCT/ES2011/070078, WO 2011/095668 A095661.
[119] Alonso, E., Vale, C., Vieytes, M. R., Laferla, F. M., Gimenez-Llort, L., and Botana, L. M. (2011) 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Abeta and hyperphosphorylated tau in vitro, Neurochem. Int. 59, 1056-1065.
[120] Alonso, E., Vale, C., Vieytes, M. R., Laferla, F. M., Gimenez-Llort, L., and Botana, L. M. (2011) The cholinergic antagonist gymnodimine improves Abeta and tau neuropathology in an in vitro model of Alzheimer disease, Cell. Physiol. Biochem. 27, 783-794.
2005-2010
[1] Wandscheer, C. B., Vilarino, N., Espina, B., Louzao, M. C., and Botana, L. M. (2010) Human muscarinic acetylcholine receptors are a target of the marine toxin 13-desmethyl C spirolide, Chem. Res. Toxicol. 23, 1753-1761.
[2] Vilarino, N., Louzao, M. C., Vieytes, M. R., and Botana, L. M. (2010) Biological methods for marine toxin detection, Anal. Bioanal. Chem. 397, 1673-1681.
[3] Vale, C., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., and Botana, L. M. (2010) Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons, Toxicol. Sci. 113, 158-168.
[4] Vale, C., and Botana, L. M. (2010) Response: The Complexity of the Cellular Effects of Azaspiracid Prevents to Highlight Only One Candidate as the Target of the Toxin, Toxicol. Sci. 115, 611-611.
[5] Vale, C., Alonso, E., Rubiolo, J. A., Vieytes, M. R., LaFerla, F. M., Gimenez-Llort, L., and Botana, L. M. (2010) Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice, Cell. Mol. Neurobiol. 30, 577-590.
[6] Touzet, N., Farrell, H., Rathaille, A. N., Rodríguez, P., Alfonso, A., Botana, L. M., and Raine, R. (2010) Dynamics of co-occurring Alexandrium minutum (Global Clade) and A. tamarense (West European) (Dinophyceae) during a summer bloom in Cork Harbour, Ireland (2006), Deep-Sea Research II 57, 268-278.
[7] Touzet, N., Farrell, H., Ní Rathaille, A., Rodriguez, P., Alfonso, A., Botana, L. M., and Raine, R. (2010) Dynamics of co-occurring Alexandrium minutum (Global Clade) and A. tamarense (West European) (Dinophyceae) during a summer bloom in Cork Harbour, Ireland (2006), Deep Sea Research Part II: Topical Studies in Oceanography 57, 268-278.
[8] Schlumberger, S., Ouanounou, G., Girard, E., Sasaki, M., Fuwa, H., Louzao, M. C., Botana, L. M., Benoit, E., and Molgo, J. (2010) The marine polyether gambierol enhances muscle contraction and blocks a transient K(+) current in skeletal muscle cells, Toxicon 56, 785-791.
[9] Rodriguez, P., Alfonso, A., Botana, A. M., Vieytes, M. R., and Botana, L. M. (2010) Comparative analysis of pre- and post-column oxidation methods for detection of paralytic shellfish toxins, Toxicon 56, 448-457.
[10] Reboreda, A., Lago, J., Chapela, M. J., Vieites, J. M., Botana, L. M., Alfonso, A., and Cabado, A. G. (2010) Decrease of marine toxin content in bivalves by industrial processes, Toxicon 55, 235-243.
[11] Otero, P., Perez, S., Alfonso, A., Vale, C., Rodriguez, P., Gouveia, N. N., Gouveia, N., Delgado, J., Vale, P., Hirama, M., Ishihara, Y., Molgo, J., and Botana, L. M. (2010) First toxin profile of ciguateric fish in Madeira Arquipelago (Europe), Anal. Chem. 82, 6032-6039.
[12] Otero, P., Alfonso, A., Vieytes, M. R., Cabado, A. G., Vieites, J. M., and Botana, L. M. (2010) Effects of environmental regimens on the toxin profile of Alexandrium ostenfeldii, Environ. Toxicol. Chem. 29, 301-310.
[13] Otero, P., Alfonso, A., Alfonso, C., Vieytes, M. R., Louzao, M. C., Botana, A. M., and Botana, L. M. (2010) New protocol to obtain spirolides from Alexandrium ostenfeldii cultures with high recovery and purity, Biomed. Chromatogr. 24, 878-886.
[14] Louzao, M. C., Espina, B., Cagide, E., Ares, I. R., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2010) Cytotoxic effect of palytoxin on mussel, Toxicon 56, 842-847.
[15] Fonfria, E. S., Vilarino, N., Molgo, J., Araoz, R., Otero, P., Espina, B., Louzao, M. C., Alvarez, M., and Botana, L. M. (2010) Detection of 13,19-didesmethyl C spirolide by fluorescence polarization using Torpedo electrocyte membranes, Anal. Biochem. 403, 102-107.
[16] Fonfria, E. S., Vilarino, N., Espina, B., Louzao, M. C., Alvarez, M., Molgo, J., Araoz, R., and Botana, L. M. (2010) Feasibility of gymnodimine and 13-desmethyl C spirolide detection by fluorescence polarization using a receptor-based assay in shellfish matrixes, Anal. Chim. Acta 657, 75-82.
[17] Espina, B., Louzao, M. C., Cagide, E., Alfonso, A., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2010) The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes, Br. J. Pharmacol. 159, 337-344.
[18] Espina, B., Louzao, M. C., Ares, I. R., Fonfria, E. S., Vilarino, N., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2010) Impact of the pectenotoxin C-43 oxidation degree on its cytotoxic effect on rat hepatocytes, Chem. Res. Toxicol. 23, 504-515.
[19] Campbell, K., Haughey, S. A., van den Top, H., van Egmond, H., Vilarino, N., Botana, L. M., and Elliott, C. T. (2010) Single laboratory validation of a surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins, Anal. Chem. 82, 2977-2988.
[20] Botana, L. M., Vilariño, N., Elliott, C. T., Campbell, K., Alfonso, A., Vale, C., Louzao, M. C., and Botana, A. M. (2010) The problem of toxicity equivalent factors in developping alternative methods to animal bioassays for marine toxin detection., Trends Anal. Chem. 29, 1316-1325.
[21] Botana, L. M., Vilariño, N., Alfonso, A., Vale, C., Louzao, C., Elliott, C. T., Campbell, K., and Botana, A. M. (2010) The problem of toxicity equivalent factors in developing alternative methods to animal bioassays for marine-toxin detection, TrAC Trends in Analytical Chemistry 29, 1316-1325.
[22] Araoz, R., Vilarino, N., Botana, L. M., and Molgo, J. (2010) Ligand-binding assays for cyanobacterial neurotoxins targeting cholinergic receptors, Anal. Bioanal. Chem. 397, 1695-1704.
[23] Alonso, E., Vale, C., Sasaki, M., Fuwa, H., Konno, Y., Perez, S., Vieytes, M. R., and Botana, L. M. (2010) Calcium oscillations induced by gambierol in cerebellar granule cells, J. Cell. Biochem. 110, 497-508.
[24] Alfonso, A., Louzao, M. C., Vieytes, M. R., Botana, A. M., and Botana, L. M. (2010) Seguridade alimentaria en moluscos: normas e mecanismos de control, In Economía pesqueira. Achegas desde un curso universitario. (García-Negro, M. C., Ed.), pp 521-538, Sotelo Blanco Edicións, Santiago de Compostela.
[25] Vilarino, N., Fonfria, E. S., Molgo, J., Araoz, R., and Botana, L. M. (2009) Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization, Anal. Chem. 81, 2708-2714.
[26] Vilarino, N., Fonfria, E. S., Louzao, M. C., and Botana, L. M. (2009) Use of biosensors as alternatives to current regulatory methods for marine biotoxins, Sensors (Basel) 9, 9414-9443.
[27] Llort, L. G., Vale, C., Rubiolo, J., Vieytes, M. R., Laferla, F. M., and Botana, L. M. (2009) Temporal profile for amyloid precursor protein, amyloid-β and tau expression in primary cultures from 3xTg-AD mice, Alzheimer´s and Dementia 5, 441.
[28] Espina, B., Cagide, E., Louzao, M. C., Fernandez, M. M., Vieytes, M. R., Katikou, P., Villar, A., Jaen, D., Maman, L., and Botana, L. M. (2009) Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells, Biosci. Rep. 29, 13-23.
[29] Cagide, E., Louzao, M. C., Espina, B., Vieytes, M. R., Jaen, D., Maman, L., Yasumoto, T., and Botana, L. M. (2009) Production of functionally active palytoxin-like compounds by Mediterranean Ostreopsis cf. siamensis, In Cell. Physiol. Biochem. 2009/05/28 ed., pp 431-440.
[30] Botana, L. M., Alonso López, E., and Vale González, C. (2009) Use of gambierol for the treatment and/or prevention of neurodegenerative diseases related with tau and beta amyloid, Patent PCT/ES2010/070634, PCT/ES2010/070634.
[31] Botana, L. M., Alfonso, A., Botana, A., Vieytes, M. R., Vale, C., Vilariño, N., and Louzao, M. C. (2009) Functional assays for marine toxins as an alternative, high-throughput screening solution to animal tests, Trends Anal. Chem. 28, 603-611.
[32] Botana, L. M. (2009) Nobuhiro Fusetani and William Kem (Eds.): Marine toxins as research tools, Anal. Bioanal. Chem. 395, 1943-1944.
[33] Ares, I. R., Cagide, E., Louzao, M. C., Espina, B., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2009) Ostreocin-D impact on globular actin of intact cells, Chem. Res. Toxicol. 22, 374-381.
[34] Alfonso, A., Vale, C., Vilariño, N., Rubiolo, J., Louzao, M. C., Vieytes, M. R., and Botana, L. M. (2009) Recent advances in marine phycotoxin mechanisms of action, In Toxines et Signalisation – Toxins and Signalling, Editions de la SFET – SFET Editions, Paris.
[35] Villar-González, A., Rodríguez-Velasco, M. L., and Botana, L. M. (2008) Pre-validación de un método de Cromatografía de Líquidos-Espectrometría de Masas para el análisis simultáneo de toxinas lipofílicas, In Avances y Tendencias en Fitoplancton Tóxico y Biotoxinas (Gilaber, J., Ed.), pp 295-302, Universidad Politécnica de Cartagena.
[36] Villar-Gonzalez, A., Rodriguez-Velasco, M. L., Ben-Gigirey, B., Yasumoto, T., and Botana, L. M. (2008) Assessment of the hydrolysis process for the determination of okadaic acid-group toxin ester: presence of okadaic acid 7-O-acyl-ester derivates in Spanish shellfish, Toxicon 51, 765-773.
[37] Vilarino, N., Nicolaou, K. C., Frederick, M. O., Cagide, E., Alfonso, C., Alonso, E., Vieytes, M. R., and Botana, L. M. (2008) Azaspiracid substituent at C1 is relevant to in vitro toxicity, Chem. Res. Toxicol. 21, 1823-1831.
[38] Vilarino, N., Ares, I. R., Cagide, E., Louzao, M. C., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2008) Induction of actin cytoskeleton rearrangement by methyl okadaate--comparison with okadaic acid, FEBS J 275, 926-934.
[39] Vale, C., Wandscheer, C., Nicolaou, K. C., Frederick, M. O., Alfonso, C., Vieytes, M. R., and Botana, L. M. (2008) Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: involvement of the c-Jun N-terminal kinase, J. Neurosci. Res. 86, 2952-2962.
[40] Vale, C., and Botana, L. M. (2008) Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins, FEBS J 275, 6060-6066.
[41] Vale, C., Alfonso, A., Vieytes, M. R., Romaris, X. M., Arevalo, F., Botana, A. M., and Botana, L. M. (2008) In vitro and in vivo evaluation of paralytic shellfish poisoning toxin potency and the influence of the pH of extraction, Anal. Chem. 80, 1770-1776.
[42] Rodríguez-Velasco, M. L., Ben-Gigirey, B., Villar-González, A., and Botana, L. M., (Eds.) (2008) Actividades del Laboratorio Comunitario de Referencia de Biotoxinas Marinas, Universidad Politécnica de Cartagena.
[43] Rodriguez, P., Alfonso, A., Vale, C., Alfonso, C., Vale, P., Tellez, A., and Botana, L. M. (2008) First toxicity report of tetrodotoxin and 5,6,11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe, Anal. Chem. 80, 5622-5629.
[44] Louzao, M. C., Espina, B., Vieytes, M. R., Vega, F. V., Rubiolo, J. A., Baba, O., Terashima, T., and Botana, L. M. (2008) "Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection, Glycoconj. J. 25, 503-510.
[45] Lober, K., Alfonso, A., Escribano, L., and Botana, L. M. (2008) STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816, J. Cell. Biochem. 103, 865-876.
[46] Lober, K., Alfonso, A., Escribano, L., and Botana, L. M. (2008) Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation, J. Cell. Biochem. 103, 1076-1088.
[47] Fonfria, E. S., Vilarino, N., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2008) Feasibility of using a surface plasmon resonance-based biosensor to detect and quantify yessotoxin, Anal. Chim. Acta 617, 167-170.
[48] Espina, B., Louzao, M. C., Ares, I. R., Cagide, E., Vieytes, M. R., Vega, F. V., Rubiolo, J. A., Miles, C. O., Suzuki, T., Yasumoto, T., and Botana, L. M. (2008) Cytoskeletal toxicity of pectenotoxins in hepatic cells, Br. J. Pharmacol. 155, 934-944.
[49] Botana, L. M. (2008) Marine toxins and the cytoskeleton, FEBS J 275, 6059.
[50] Botana, L. M. (2008) The mouse bioassay as a universal detector., In Seafood and Freshwater toxins: Pharmacology, Physiology and Detection (Botana, L. M., Ed.) 2nd edition ed., pp 149-161, CRC Press (Taylor and Francis Group), Boca Raton, FL.
[51] Alonso, E., Alfonso, A., Lober, K., and Botana, L. M. (2008) The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect, J. Cell. Biochem. 105, 255-261.
[52] Alfonso, C., Rehmann, N., Hess, P., Alfonso, A., Wandscheer, C. B., Abuin, M., Vale, C., Otero, P., Vieytes, M. R., and Botana, L. M. (2008) Evaluation of various pH and temperature conditions on the stability of azaspiracids and their importance in preparative isolation and toxicological studies, Anal. Chem. 80, 9672-9680.
[53] Alfonso, C., Alfonso, A., Otero, P., Rodriguez, P., Vieytes, M. R., Elliot, C., Higgins, C., and Botana, L. M. (2008) Purification of five azaspiracids from mussel samples contaminated with DSP toxins and azaspiracids, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 865, 133-140.
[54] Villar-Gonzalez, A., Rodriguez-Velasco, M. L., Ben-Gigirey, B., and Botana, L. M. (2007) Lipophilic toxin profile in Galicia (Spain): 2005 toxic episode, Toxicon 49, 1129-1134.
[55] Vilarino, N., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., and Botana, L. M. (2007) Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells, Biochem. Pharmacol. 74, 327-335.
[56] Vale-Gonzalez, C., Pazos, M. J., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2007) Study of the neuronal effects of ouabain and palytoxin and their binding to Na,K-ATPases using an optical biosensor, Toxicon 50, 541-552.
[57] Vale-Gonzalez, C., Gomez-Limia, B., Vieytes, M. R., and Botana, L. M. (2007) Effects of the marine phycotoxin palytoxin on neuronal pH in primary cultures of cerebellar granule cells, J. Neurosci. Res. 85, 90-98.
[58] Vale, C., Nicolaou, K. C., Frederick, M. O., Gomez-Limia, B., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2007) Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study, J. Med. Chem. 50, 356-363.
[59] Vale, C., Gomez-Limia, B., Vieytes, M. R., and Botana, L. M. (2007) Mitogen-activated protein kinases regulate palytoxin-induced calcium influx and cytotoxicity in cultured neurons, Br. J. Pharmacol. 152, 256-266.
[60] Vale, C., Gomez-Limia, B., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., and Botana, L. M. (2007) The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1, Cell. Physiol. Biochem. 20, 957-966.
[61] Schlumberger, S., Girard, E., Bournaud, R., Sasaki, M., Fuwa, H., Cagide, E., Louzao, M. C., Botana, L. M., Molgó, J., and Benoit, E. (2007) Effects du gambierol sur les canaux potassium et la libération de neurotransmetteurs. [Effects of gambierol on potassium channels and neurotransmitter release], In Toxines émergentes: nouveaux risques (Goudey-Perriére, F., Benoit, E., Marchot, P., and Popoff, M. R., Eds.), pp 157-158, Lavoisier. Editions TEC & DOC, Paris.
[62] Melgarejo, E., Medina, M. A., Sanchez-Jimenez, F., Botana, L. M., Dominguez, M., Escribano, L., Orfao, A., and Urdiales, J. L. (2007) (-)-Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes, Cell. Mol. Life Sci. 64, 2690-2701.
[63] Louzao, M. C., Ares, I. R., Vieytes, M. R., Valverde, I., Vieites, J. M., Yasumoto, T., and Botana, L. M. (2007) The cytoskeleton, a structure that is susceptible to the toxic mechanism activated by palytoxins in human excitable cells, FEBS J 274, 1991-2004.
[64] Llamas, N. M., Stewart, L., Fodey, T., Higgins, H. C., Velasco, M. L., Botana, L. M., and Elliott, C. T. (2007) Development of a novel immunobiosensor method for the rapid detection of okadaic acid contamination in shellfish extracts, Anal. Bioanal. Chem. 389, 581-587.
[65] Fonfria, E. S., Vilarino, N., Campbell, K., Elliott, C., Haughey, S. A., Ben-Gigirey, B., Vieites, J. M., Kawatsu, K., and Botana, L. M. (2007) Paralytic shellfish poisoning detection by surface plasmon resonance-based biosensors in shellfish matrixes, Anal. Chem. 79, 6303-6311.
[66] Cagide, E., Louzao, M. C., Ares, I. R., Vieytes, M. R., Yotsu-Yamashita, M., Paquette, L. A., Yasumoto, T., and Botana, L. M. (2007) Effects of a synthetic analog of polycavernoside A on human neuroblastoma cells, Cell. Physiol. Biochem. 19, 185-194.
[67] Botana, L. M., Vale, C., and Vilariño, N. (2007) Mechanism of action of palytoxin and azaspiracids, In Toxines émergentes: nouveaux risques (Goudey-Perriére, F., Benoit, E., Marchot, P., and Popoff, M. R., Eds.), pp 149-156, Lavoisier. Editions TEC & DOC, Paris.
[68] Ben-Gigirey, B., Rodriguez-Velasco, M. L., Villar-Gonzalez, A., and Botana, L. M. (2007) Influence of the sample toxic profile on the suitability of a high performance liquid chromatography method for official paralytic shellfish toxins control, J. Chromatogr. A 1140, 78-87.
[69] Ares, I. R., Louzao, M. C., Espina, B., Vieytes, M. R., Miles, C. O., Yasumoto, T., and Botana, L. (2007) Lactone ring of pectenotoxins: a key factor for their activity on cytoskeletal dynamics, Cell. Physiol. Biochem. 19, 283-292.
[70] Alfonso, C., Alfonso, A., Pazos, M. J., Vieytes, M. R., Yasumoto, T., Milandri, A., Poletti, R., and Botana, L. M. (2007) Extraction and cleaning methods to detect yessotoxins in contaminated mussels, Anal. Biochem. 363, 228-238.
[71] Villar Gonzalez, A., Rodriguez-Velasco, M. L., Ben-Gigirey, B., and Botana, L. M. (2006) First evidence of spirolides in Spanish shellfish, Toxicon 48, 1068-1074.
[72] Vilarino, N., Nicolaou, K. C., Frederick, M. O., Cagide, E., Ares, I. R., Louzao, M. C., Vieytes, M. R., and Botana, L. M. (2006) Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies, Chem. Res. Toxicol. 19, 1459-1466.
[73] Vale-Gonzalez, C., Alfonso, A., Sunol, C., Vieytes, M. R., and Botana, L. M. (2006) Role of the plasma membrane calcium adenosine triphosphatase on domoate-induced intracellular acidification in primary cultures of cerebelar granule cells, J. Neurosci. Res. 84, 326-337.
[74] Vale, C., Alfonso, A., Sunol, C., Vieytes, M. R., and Botana, L. M. (2006) Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin, J. Neurosci. Res. 83, 1393-1406.
[75] Pernas-Sueiras, O., Alfonso, A., Vieytes, M. R., Orfao, A., Escribano, L., Francisca, S. J., and Botana, L. M. (2006) Calcium-pH crosstalks in the human mast cell line HMC-1: intracellular alkalinization activates calcium extrusion through the plasma membrane Ca2+-ATPase, J. Cell. Biochem. 99, 1397-1408.
[76] Pernas-Sueiras, O., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2006) PKC and cAMP positively modulate alkaline-induced exocytosis in the human mast cell line HMC-1, J. Cell. Biochem. 99, 1651-1663.
[77] Pazos, M. J., Alfonso, A., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2006) Study of the interaction between different phosphodiesterases and yessotoxin using a resonant mirror biosensor, Chem. Res. Toxicol. 19, 794-800.
[78] Louzao, M. C., Vieytes, M. R., Yasumoto, T., Yotsu-Yamashita, M., and Botana, L. M. (2006) Changes in membrane potential: an early signal triggered by neurologically active phycotoxins, Chem. Res. Toxicol. 19, 788-793.
[79] Louzao, M. C., Cagide, E., Vieytes, M. R., Sasaki, M., Fuwa, H., Yasumoto, T., and Botana, L. M. (2006) The sodium channel of human excitable cells is a target for gambierol, Cell. Physiol. Biochem. 17, 257-268.
[80] Hess, P., Grune, B., Anderson, D. B., Aune, T., Botana, L. M., Caricato, P., van Egmond, H. P., Halder, M., Hall, S., Lawrence, J. F., Moffat, C., Poletti, R., Richmond, J., Rossini, G. P., Seamer, C., Vilageliu, J. S., and Workshop, E. D. S. (2006) Three Rs Approaches in Marine Biotoxin Testing. The Report and Recommendations of a joint ECVAM/DG SANCO Workshop (ECVAM Workshop 54), Altern Lab Anim 34, 193-224.
[81] Garcia-Montero, A. C., Jara-Acevedo, M., Teodosio, C., Sanchez, M. L., Nunez, R., Prados, A., Aldanondo, I., Sanchez, L., Dominguez, M., Botana, L. M., Sanchez-Jimenez, F., Sotlar, K., Almeida, J., Escribano, L., and Orfao, A. (2006) KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients, Blood 108, 2366-2372.
[82] Alfonso, A., Vieytes, M. R., Ofuji, K., Satake, M., Nicolaou, K. C., Frederick, M. O., and Botana, L. M. (2006) Azaspiracids modulate intracellular pH levels in human lymphocytes, Biochem. Biophys. Res. Commun. 346, 1091-1099.
2000-2005
[1] Pernas-Sueiras, O., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2005) Mast cell exocytosis can be triggered by ammonium chloride with just a cytosolic alkalinization and no calcium increase, J. Cell. Physiol. 204, 775-784.
[2] Pazos, M. J., Alfonso, A., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2005) Kinetic analysis of the interaction between yessotoxin and analogues and immobilized phosphodiesterases using a resonant mirror optical biosensor, Chem. Res. Toxicol. 18, 1155-1160.
[3] Louzao, M. C., Vieytes, M. R., and Botana, L. M. (2005) Effect of okadaic acid on glucose regulation, Mini Rev. Med. Chem. 5, 207-215.
[4] Ares, I. R., Louzao, M. C., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2005) Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins, J. Exp. Biol. 208, 4345-4354.
[5] Alfonso, C., Alfonso, A., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2005) Quantification of yessotoxin using the fluorescence polarization technique and study of the adequate extraction procedure, Anal. Biochem. 344, 266-274.
[6] Alfonso, A., Vieytes, M. R., and Botana, L. M. (2005) Calcium-pH crosstalks in rat mast cells: modulation by transduction signals show non-essential role for calcium in alkaline-induced exocytosis, Biochem. Pharmacol. 69, 319-327.
[7] Alfonso, A., Roman, Y., Vieytes, M. R., Ofuji, K., Satake, M., Yasumoto, T., and Botana, L. M. (2005) Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes, Biochem. Pharmacol. 69, 1627-1636.
[8] Roman, Y., Alfonso, A., Vieytes, M. R., Ofuji, K., Satake, M., Yasumoto, T., and Botana, L. M. (2004) Effects of Azaspiracids 2 and 3 on intracellular cAMP, [Ca2+], and pH, Chem. Res. Toxicol. 17, 1338-1349.
[9] Pazos, M. J., Alfonso, A., Vieytes, M. R., Yasumoto, T., Vieites, J. M., and Botana, L. M. (2004) Resonant mirror biosensor detection method based on yessotoxin-phosphodiesterase interactions, Anal. Biochem. 335, 112-118.
[10] Louzao, M. C., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2004) Detection of sodium channel activators by a rapid fluorimetric microplate assay, Chem. Res. Toxicol. 17, 572-578.
[11] Cabado, A. G., Leira, F., Vieytes, M. R., Vieites, J. M., and Botana, L. M. (2004) Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells, Arch. Toxicol. 78, 74-85.
[12] Botana, L. M., Vieytes, M. R., Louzao, M. C., and Alfonso, A. (2004) Phycotoxins., In Handbook of Food Analysis. (Nollet, L., Ed.), pp 911-930, Marcel Dekker Inc., London.
[13] Botana, L. M., Alfonso, A., Vieytes, M. R., and Loza, M. I. (2004) Therapeutic use of yessotoxins as growth inhibitors of human tumoral cells, In Patent (Compostela, U. o. S. d., Ed.).
[14] Botana, L. M., Alfonso, A., Vieytes, M. R., and Loza, M. I. (2004) Therapeutic use of yessotoxins in the treatment of allergic and ashmatic processes, Patent PCT/ES 2004/000343, PCT/ES 2004/000343.
[15] Alfonso, A., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2004) A rapid microplate fluorescence method to detect yessotoxins based on their capacity to activate phosphodiesterases, Anal. Biochem. 326, 93-99.
[16] Vilarino, N., de la Rosa, L. A., Vieytes, M. R., and Botana, L. M. (2003) The Cl-HCO3- exchanger slows the recovery of acute pHi changes in rat mast cells, Biochem. Pharmacol. 65, 389-396.
[17] Louzao, M. C., Vieytes, M. R., Fontal, O., and Botana, L. M. (2003) Glucose uptake in enterocytes: a test for molecular targets of okadaic acid, J. Recept. Signal Transduct. Res. 23, 211-224.
[18] Louzao, M. C., Rodriguez Vieytes, M., Garcia Cabado, A., Vieites Baptista De Sousa, J. M., and Botana, L. M. (2003) A fluorimetric microplate assay for detection and quantitation of toxins causing paralytic shellfish poisoning, Chem. Res. Toxicol. 16, 433-438.
[19] Leira, F., Alvarez, C., Cabado, A. G., Vieites, J. M., Vieytes, M. R., and Botana, L. M. (2003) Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins, Anal. Biochem. 317, 129-135.
[20] Gonzalez-Gay, M. A., Hajeer, A. H., Garcia-Porrua, C., Dababneh, A., Amoli, M. M., Botana, M. A., Thomson, W., Llorca, J., and Ollier, W. E. (2003) Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain, J. Rheumatol. 30, 913-917.
[21] Cabado, A. G., Leira, F., Vieites, J. M., Vieytes, M. R., and Botana, L. M. (2003) Capase-8 activation initiates okadaic acid-induced apoptosis in neuroblastoma, In Molluscan Shellfish Safety (Proceedings of the 4th international conference on molluscan shellfish safety), pp 83-93.
[22] Alfonso, A., De la Rosa, L. A., Vieytes, M. R., and Botana, L. M. (2003) Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes, Biochem. Pharmacol. 65, 465-478.
[23] Alfonso, A., de la Rosa, L., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2003) Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes, Biochem. Pharmacol. 65, 193-208.
[24] Roman, Y., Alfonso, A., Louzao, M. C., de la Rosa, L. A., Leira, F., Vieites, J. M., Vieytes, M. R., Ofuji, K., Satake, M., Yasumoto, T., and Botana, L. M. (2002) Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets, Cell. Signal. 14, 703-716.
[25] Leira, F., Louzao, M. C., Vieites, J. M., Botana, L. M., and Vieytes, M. R. (2002) Fluorescent microplate cell assay to measure uptake and metabolism of glucose in normal human lung fibroblasts, Toxicol. In Vitro 16, 267-273.
[26] Leira, F., Cabado, A. G., Vieytes, M. R., Roman, Y., Alfonso, A., Botana, L. M., Yasumoto, T., Malaguti, C., and Rossini, G. P. (2002) Characterization of F-actin depolymerization as a major toxic event induced by pectenotoxin-6 in neuroblastoma cells, Biochem. Pharmacol. 63, 1979-1988.
[27] Leira, F., Alvarez, C., Vieites, J. M., Vieytes, M. R., and Botana, L. M. (2002) Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line, Toxicol. In Vitro 16, 23-31.
[28] Landoni, M. F., Honrubia, M. A., Simpson, M. I., and Botana, L. M. (2002) Relación estructura química-acitvidad, In Farmacología y Terapéutica Veterinaria (Botana, L. M., Landoni, F., and Martín-Jiménez, T., Eds.), pp 20-29, MacGraw-Hill-Interamericana, Madrid.
[29] Honrubia, M. A., and Botana, L. M. (2002) Aspectos técnicos del desarrollo de un fármaco veterinario, In Farmacología y Terapéutica Veterinaria (Botana, L. M., Landoni, F., and Martín-Jiménez, T., Eds.), MacGraw-Hill-Interamericana, Madrid.
[30] González, J. C., Leira, F., Fontal, O. I., Vieytes, M. R., Arévalo, F. F., Vieites, J. M., Bermúdez-Puente, M., Muñiz, S., Salgado, C., Yasumoto, T., and Botana, L. M. (2002) Inter-laboratory validation of the fluorescent protein phosphatase inhibition assay to determine diarrhetic shellfish-toxins: intercomparison with liquid chromatography and mouse bioassay, Anal. Chim. Acta 466, 233-246.
[31] Gonzalez, J. C., Fontal, O. I., Vieytes, M. R., Vieites, J. M., and Botana, L. M. (2002) Basis for a new procedure to eliminate diarrheic shellfish toxins from a contaminated matrix, J. Agric. Food Chem. 50, 400-405.
[32] de La Rosa, A., Vilarino, N., Vieytes, R., and Botana, M. (2002) Okadaic acid, a protein phosphatase inhibitor, stimulates the activity of Na+/H+ and Na+-independent Cl-/HCO3- exchangers in human lymphocytes, Naunyn Schmiedebergs Arch. Pharmacol. 365, 74-81.
[33] Botana, L. M., Landoni, F., and Matín-Jiménez, T. (2002) Farmacología y Terapéutica Veterinaria, 1ª ed., MacGraw-Hill-Interamericana, Madrid.
[34] Botana, J. C., Pereiro, I. R., and Torrijos, R. C. (2002) Rapid determination of butyltin species in water samples by multicapillary gas chromatography with atomic emission detection following headspace solid-phase microextraction, J. Chromatogr. A 963, 195-203.
[35] Vilarino, N., De la Rosa, L. A., Vieytes, M. R., and Botana, L. M. (2001) HCO3(-) ions increase mast cell sensitivity to thapsigargin-induced Ca(2+) entry, Biochem. Biophys. Res. Commun. 280, 518-521.
[36] Vilarino, N., de la Rosa, L. A., Vieytes, M. R., and Botana, L. M. (2001) HCO(3)(-) ions modify the role of PKC isoforms in the modulation of rat mast cell functions, Cell. Signal. 13, 177-190.
[37] Roman, Y., Alfonso, A., Louzao, M. C., Vieytes, M. R., and Botana, L. M. (2001) Confocal microscopy study of the different patterns of 2-NBDG uptake in rabbit enterocytes in the apical and basal zone, Pflugers Arch. 443, 234-239.
[38] Quintela, J. M., Peinador, C., Moreira, M. J., Alfonso, A., Botana, L. M., and Riguera, R. (2001) Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity, Eur. J. Med. Chem. 36, 321-332.
[39] Louzao, M. C., Vieytes, M. R., Baptista de Sousa, J. M., Leira, F., and Botana, L. M. (2001) A fluorimetric method based on changes in membrane potential for screening paralytic shellfish toxins in mussels, Anal. Biochem. 289, 246-250.
[40] Leira, F., Vieites, J. M., Vieytes, M. R., and Botana, L. M. (2001) Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts, Toxicol. In Vitro 15, 199-208.
[41] Leira, F., Alvarez, C., Vieites, J. M., Vieytes, M. R., and Botana, L. M. (2001) Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay, Toxicol. In Vitro 15, 277-282.
[42] Lago, J., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2001) Ouabain-induced enhancement of rat mast cells response. Modulation by protein phosphorylation and intracellular pH, Cell. Signal. 13, 515-524.
[43] González, J. C., Vieytes, M. R., Vieites, J. M., and Botana, L. M. (2001) Solubility of the diarrheic shellfish toxin okadaic acid in supercritical CO2, J. Am. Oil Chem. Soc. 78, 77-81.
[44] Gonzalez, J. C., Vieytes, M. R., Botana, A. M., Vieites, J. M., and Botana, L. M. (2001) Modified mass action law-based model to correlate the solubility of solids and liquids in entrained supercritical carbon dioxide, J. Chromatogr. A 910, 119-125.
[45] de la Rosa, L. A., Vilarino, N., Vieytes, M. R., and Botana, L. M. (2001) Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89, Cell. Signal. 13, 441-449.
[46] de la Rosa, L. A., Alfonso, A., Vilarino, N., Vieytes, M. R., Yasumoto, T., and Botana, L. M. (2001) Maitotoxin-induced calcium entry in human lymphocytes: modulation by yessotoxin, Ca(2+) channel blockers and kinases, Cell. Signal. 13, 711-716.
[47] de la Rosa, L. A., Alfonso, A., Vilarino, N., Vieytes, M. R., and Botana, L. M. (2001) Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin, Biochem. Pharmacol. 61, 827-833.
[48] Alfonso, A., Botana, M. A., Vieytes, M. R., and Botana, L. M. (2001) Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases, Cell. Signal. 13, 819-826.
[49] Vieytes, M. R., Louzao, M. C., Alfonso, A., Cabado, A. G., and Botana, L. M. (2000) Enteric toxic episodes. Mechanism of action and toxicology., In Seafood and freshwater toxins: pharmacology, physiology and detection. (Botana, L. M., Ed.), pp 239-256, Marcel Dekker, New York.
[50] Leira, F., Vieites, J. M., Vieytes, M. R., and Botana, L. M. (2000) Characterization of 9H-(1,3-dichlor-9, 9-dimethylacridin-2-ona-7-yl)-phosphate (DDAO) as substrate of PP-2A in a fluorimetric microplate assay for diarrhetic shellfish toxins (DSP), Toxicon 38, 1833-1844.
[51] Gonzalez, J. C., Leira, F., Vieytes, M. R., Vieites, J. M., Botana, A. M., and Botana, L. M. (2000) Development and validation of a high-performance liquid chromatographic method using fluorimetric detection for the determination of the diarrhetic shellfish poisoning toxin okadaic acid without chlorinated solvents, J. Chromatogr. A 876, 117-125.
[52] Cabado, A. G., Alfonso, A., Vieytes, M. R., Gonzalez, M., Botana, M. A., and Botana, L. M. (2000) Crosstalk between cytosolic pH and intracellular calcium in human lymphocytes: effect of 4-aminopyridin, ammoniun chloride and ionomycin, Cell. Signal. 12, 573-581.
[53] Cabado, A. G., Alfonso, A., Vieytes, M. R., and Botana, L. M. (2000) Hypertonicity-induced intracellular pH changes in rat mast cells, Life Sci. 67, 1969-1982.
[54] Botana, L. M., (Ed.) (2000) Seafood and freshwater toxins. Pharmacology, physiology and detection., Marcel Dekker, New York.
[55] Alfonso, A., Cabado, A. G., Vieytes, M. R., and Botana, L. M. (2000) Functional compartments in rat mast cells for cAMP and calcium on histamine release, Cell. Signal. 12, 343-350.
[56] Alfonso, A., Cabado, A. G., Vieytes, M. R., and Botana, L. M. (2000) Calcium-pH crosstalks in rat mast cells: cytosolic alkalinization, but not intracellular calcium release, is a sufficient signal for degranulation, Br. J. Pharmacol. 130, 1809-1816.
->2000
[1] Vilarino, N., Vieytes, M. R., Vieites, J. M., and Botana, L. M. (1999) Modulatory effect of HCO3- on rat mast cell exocytosis: cross-talks between bicarbonate and calcium, Biochem. Biophys. Res. Commun. 260, 71-79.
[2] Vieites, J. M., Botana, L. M., Vieytes, M. R., and Leira, F. J. (1999) Canning process that diminishes paralytic shellfish poison in naturally contaminated mussels (Mytilus galloprovincialis), J. Food Prot. 62, 515-519.
[3] Fontal, O. I., Vieytes, M. R., Baptista de Sousa, J. M., Louzao, M. C., and Botana, L. M. (1999) A fluorescent microplate assay for microcystin-LR, Anal. Biochem. 269, 289-296.
[4] de la Rosa, L. A., Cabado, A. G., Botana, M. A., Vieytes, M. R., Vidal, J. I., and Botana, L. M. (1999) Evidence for an electrogenic, negatively protein-kinase-A-modulated, Na+-dependent HCO3- transporter in human lymphocytes, Pflugers Arch. 437, 935-943.
[5] Cabado, A. G., Despa, S., Botana, M. A., Vieytes, M. R., Gonzalez, M., and Botana, L. M. (1999) Membrane potential changes associated with calcium signals in human lymphocytes and rat mast cells, Life Sci. 64, 681-696.
[6] Botana, L. M., Fontal, O. I., Alfonso, A., de la Rosa, L. A., Vieytes, M. R., Baptista de Sousa, J. M. V., Leira, F., and Louzao, M. C. (1999) Seafood Biotoxins: Dose-Response Assesment., In Foodborne Illnes (Cabral, R., Ed.) 1st ed., pp 43-57, Fac. Ciencias Nutricao e Alimentacao, Univ. Porto, Porto.
[7] Botana, L. M. (1999) Biotoxinas marinas., In ANFACO-CECOPESCA, 50 años. Foro Internacional de la conservación de productos de la pesca de Galicia. (ANFACO, Ed.), pp 171-184, Publicaciones Vigo., Vigo.
[8] Alfonso, A., Lago, J., Botana, M. A., Vieytes, M. R., and Botana, L. M. (1999) Characterization of the Na+/Ca2+ exchanger on rat mast cells. Evidence for a functional role on the regulation of the cellular response, Cell. Physiol. Biochem. 9, 53-71.
[9] Vilarino, N., Vieytes, M. R., Vieites, J. M., and Botana, L. M. (1998) Role of HCO3- ions in cytosolic pH regulation in rat mast cells: evidence for a new Na+-independent, HCO3--dependent alkalinizing mechanism, Biochem. Biophys. Res. Commun. 253, 320-324.
[10] Vieytes, M. R., Fontal, O. I., Leira, F., Vieites, J. M., and Botana, L. M. (1998) A fluorescent microplate assay for diarrhetic shellfish toxins., In Harmful Algae (Reguera, B., Blanco, J., Fernández, M. L., and Wyatt, T., Eds.), pp 533-536, Xunta de Galicia-Intergovernmental Oceanographic Commission of UNESCO 1998, Vigo.
[11] Quintela, J. M., Peinador, C., Veiga, M. C., Botana, L. M., Alfonso, A., and Riguera, R. (1998) Synthesis, antihistaminic and cytotoxic activity of pyridothieno- and pyridodithienotriazines., Eur. J. Med. Chem. 33, 887-897.
[12] Quintela, J. M., Peinador, C., Veiga, C., Gonzalez, L., Botana, L. M., Alfonso, A., and Riguera, R. (1998) Synthesis and antiallergic activity of pyridothienopyrimidines, Bioorg. Med. Chem. 6, 1911-1925.
[13] Louzao, M. C., Vieytes, M. R., and Botana, L. M. (1998) Sodium-glucose cotransport in animal cells., In Trends in Comparative Biochem. & Physiol., Vol. 5 (Brittain, T., Huddart, H., Nässel, D. R., Takeuchi, H., and Taylor, E. W., Eds.), pp 275-282, Research Trends, Trivandrum.
[14] Leira, F. J., Vieites, J. M., Botana, L. M., and Vieytes, M. R. (1998) Domoic acid levels of naturally contaminated scallops as affected by canning, J. Food Sci. 63, 1081-1083.
[15] Gonzalez, J. C., Vieytes, M. R., Vieites, J. M., and Botana, L. M. (1998) Improvement on sample clean-up for high-performance liquid chromatographic-fluorimetric determination of diarrhetic shellfish toxins using 1-bromoacetylpyrene, J. Chromatogr. A 793, 63-70.
[16] González, J. C., Vieites, J. M., Botana, A. M., Vieytes, M. R., and Botana, L. M. (1998) Improved sample clean up in the HPLC/Fluorimetric determination of okadaic acid using 1-bromoacetylpyrene as derivatizing reagent., In Harmful Algae (Reguera, B., Blanco, J., Fernández, M. L., and Wyatt, T., Eds.), pp 521-522, Xunta de Galicia-Intergovernmental Oceanographic Commission of UNESCO 1998, Vigo.
[17] Fontal, O. I., Leira, F., González, J. C., Vieytes, M. R., Vieites, J. M., and Botana, L. M. (1998) Determination of okadaic acid levels by HPLC and fluorescent microplate assay: a comparison of both methods., In Harmful Algae (Reguera, B., Blanco, J., Fernández, M. L., and Wyatt, T., Eds.), pp 547-548, Xunta de Galicia-Intergovernmental Oceanographic Commission of UNESCO 1998, Vigo.
[18] Cabado, A. G., Vieytes, M. R., and Botana, L. M. (1998) Inhibition of Na+/K+ ATPase under hypertonic conditions in rat mast cells, Life Sci. 63, 1227-1237.
[19] Alfonso, A., Botana, M. A., Vieytes, M. R., and Botana, L. M. (1998) Sodium, PMA and calcium play an important role on intracellular pH modulation in rat mast cells, Cell. Physiol. Biochem. 8, 314-327.
[20] Vieytes, M. R., Fontal, O. I., Leira, F., Baptista de Sousa, J. M., and Botana, L. M. (1997) A fluorescent microplate assay for diarrheic shellfish toxins, Anal. Biochem. 248, 258-264.
[21] Quintela, J. M., Peinador, C., Botana, L., Estevez, M., and Riguera, R. (1997) Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3-d]-pyrimidines, Bioorg. Med. Chem. 5, 1543-1553.
[22] Mazoy, R., Botana, L. M., and Lemos, M. L. (1997) Iron uptake from ferric citrate by Vibrio anguillarum., FEMS Microbiol. Lett. 154, 145-150.
[23] Estevez, M. D., Vieytes, M. R., Louzao, M. C., Alfonso, A., Vilarino, N., and Botana, L. M. (1997) The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells, Inflamm. Res. 46, 119-124.
[24] Botana, L. M., Vieytes, M. R., Vieites, J. M., and Leira, F. (1997) Ensayo fluorescente en placa de microtiter para el análisis de toxinas diarreicas (DSP), Proceedings V Reunión Ibérica de Fitoplancton Tóxico y Biotoxinas, Vigo, 6-7 Febrero., 115-119.
[25] Vieites, J. M., Leira, F., Botana, L. M., and Vieytes, M. R. (1996) Determination of DSP toxins: comparative study of HPLC and bioassay to reduce the observation time of the mouse bioassay, Arch. Toxicol. 70, 440-443.
[26] Estevez, M. D., Vieytes, M. R., and Botana, L. M. (1996) Mitoxantrone induces nonimmunological histamine release from rat mast cells, Inflamm. Res. 45, 113-117.
[27] Botana, L. M., Vieytes, M. R., Alfonso, A., and Louzao, M. C. (1996) Phycotoxins. Paralytic Shellfish Poisoning. Diarrhetic Shellfish Poisoning., In Handbook of Food Analysis. (Nollet, L., Ed.), pp 1147-1170, Marcel Dekker Inc., London.
[28] Rodriguez-Pena, A., Botana, M., Gonzalez, M., and Requejo, F. (1995) Expression of neurotrophins and their receptors in sciatic nerve of experimentally diabetic rats, Neurosci. Lett. 200, 37-40.
[29] Estevez, M. D., Alfonso, A., Vieytes, M. R., Louzao, M. C., and Botana, L. M. (1995) Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release, Inflamm. Res. 44, 87-91.
[30] Alfonso, A., Estevez, M., Louzao, M. C., Vieytes, M. R., and Botana, L. M. (1995) Determination of phosphodiesterase activity in rat mast cells using the fluorescent cAMP analogue anthraniloyl cAMP, Cell. Signal. 7, 513-518.
[31] Louzao, M. C., Alfonso, A., Cabado, A. G., Botana, A. M., Goenaga, X., Vieytes, M. R., and Botana, L. M. (1994) Study of the stability of gonyautoxins in acidic solution., Fres. J. Anal. Chem. 349, 465-468.
[32] Louzao, M. C., Alfonso, A., Botana, A. M., Goenaga, X., Cabado, A. G., Vieytes, M. R., and Botana, L. M. (1994) Effect of lyophilization on the stability of gonyautoxins obtained from contaminated mussels, Toxicon 32, 807-817.
[33] Estevez, M. D., Vieytes, M. R., Louzao, M. C., and Botana, L. M. (1994) Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells, Biochem. Pharmacol. 47, 591-593.
[34] Estevez, M. D., Vieytes, M. R., and Botana, L. M. (1994) Study of the activation mechanism of adriamycin on rat mast cells, Agents Actions 42, 86-91.
[35] Columbo, M., Botana, L. M., Horowitz, E. M., Lichtenstein, L. M., and MacGlashan, D. W., Jr. (1994) Studies of the intracellular Ca2+ levels in human adult skin mast cells activated by the ligand for the human c-kit receptor and anti-IgE, Biochem. Pharmacol. 47, 2137-2145.
[36] Cabado, A. G., Vieytes, M. R., and Botana, L. M. (1994) Effect of ion composition on the changes in membrane potential induced with several stimuli in rat mast cells, J. Cell. Physiol. 158, 309-316.
[37] Botana, L. M., and MacGlashan, D. W. (1994) Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils, J. Leukoc. Biol. 55, 798-804.
[38] Alfonso, A., Louzao, M. C., Vieytes, M. R., and Botana, L. M. (1994) Comparative study of the stability of saxitoxin and neosaxitoxin in acidic solutions and lyophilized samples, Toxicon 32, 1593-1598.
[39] Alfonso, A., Botana, M. A., Vieytes, M. R., Louzao, M. C., and Botana, L. M. (1994) Effect of signal transduction pathways on the action of thapsigargin on rat mast cells. Crosstalks between cellular signalling and cytosolic pH, Biochem. Pharmacol. 47, 1813-1820.
[40] Alfonso, A., Botana, M. A., Vieytes, M. R., and Botana, L. M. (1994) Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways, Eur. J. Pharmacol. 267, 289-296.
[41] Vieytes, M. R., Cabado, A. G., Alfonso, A., Louzao, M. C., Botana, A. M., and Botana, L. M. (1993) Solid-phase radioreceptor assay for paralytic shellfish toxins, Anal. Biochem. 211, 87-93.
[42] MacGlashan, D., Jr., and Botana, L. M. (1993) Biphasic Ca2+ responses in human basophils. Evidence that the initial transient elevation associated with the mobilization of intracellular calcium is an insufficient signal for degranulation, J. Immunol. 150, 980-991.
[43] Louzao, M. C., Vieytes, M. R., and Botana, L. M. (1993) D-glucose transport of mussel mantle cell membranes: interaction of sodium and phlorizin., J. Exp. Zool. 267, 572-577.
[44] Louzao, M. C., Vieytes, M. R., Alfonso, A., and Botana, L. M. (1993) Characterization of the Na+-H+ antiporter in cells of the mussel Mytilus Galloprovincialis., Comp. Biochem. Physiol. 104A, 101-104.
[45] Estevez, M. D., Botana, M. A., Arnaez, E., Vieytes, M. R., and Botana, L. M. (1993) Histamine release on rat pleural and peritoneal mast cells elicited by human GRF(1-29)NH2, Int. Arch. Allergy Immunol. 100, 86-88.
[46] Cabado, A. G., Vieytes, M. R., and Botana, L. M. (1993) Rat pleural and peritoneal mast cells stimulated at different cellular levels: difference in and influence of purification media, Int. Arch. Allergy Immunol. 100, 234-239.
[47] Cabado, A. G., Vieytes, M. R., and Botana, L. M. (1993) Amiloride-dependent transport is the main mechanism implicated in sodium influx regulation in rat mast cells, J. Cell. Physiol. 156, 567-570.
[48] Botana, L. M., and MacGlashan, D. W., Jr. (1993) Effect of okadaic acid on human basophil secretion, Biochem. Pharmacol. 45, 2311-2315.
[49] Alfonso, A., Vieytes, M. R., Botana, A. M., Goenaga, X., and Botana, L. M. (1993) Preparation of mixtures of paralytic shellfish toxin (PSP) standards from mussel hepatopancreas., Fresenius J. Anal. Chem. 345, 212-216.
[50] Alfonso, A., Vieytes, M. R., Botana, A. M., Goenaga, X., and Botana, L. M. (1993) PSP chromatograms, Recorder 76, 314-316.
[51] Louzao, M. C., Vieytes, M. R., and Botana, L. M. (1992) Evidence of modulatory activity in the nervous system of the crab, Carcinus maenas: changes in saxitoxin binding in central nervous ganglia., Dendron 1, 47-54.
[52] Louzao, M. C., Corona-López, P. P., Vieytes, M. R., and Botana, L. M. (1992) Unión de saxitoxina a receptores de fracciones celulares de hepatopáncreas de mejillón Mytilus galloprovincialis Lmk., Cuadernos Ciencias Marinas 6, 65-72.
[53] De la Cruz, L. F., and Botana, L. M., (Eds.) (1992) Fisiología y farmacología de algunas hormonas utilizadas en veterinaria., Vol. 14, 1 ed., Universidad de Santiago, Santiago de Compostela.
[54] Columbo, M., Horowitz, E. M., Botana, L. M., MacGlashan, D. W., Jr., Bochner, B. S., Gillis, S., Zsebo, K. M., Galli, S. J., and Lichtenstein, L. M. (1992) The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils, J. Immunol. 149, 599-608.
[55] Columbo, M., Horowitz, E. M., Botana, L. M., MacGlashan, D. J., Bochner, B. S., Gillis, S., Zsebo, K. M., Galli, S. J., and Lichtenstein, L. M. (1992) Effect of recombinant human c-kit receptor ligand on mediator release from human skin mast cells, Int. Arch. Allergy Immunol. 99, 323-325.
[56] Botana, L. M., López-Corona, P. P., Louzao, M. C., Román, A., and Vieytes, M. R. (1992) Tipificación de los receptores para saxitoxina en las células de manto de mejillón (Mytilus galloprovincialis), Cuadernos de Ciencias Marinas 6, 73-80.
[57] Botana, L. M., Arnaez, E., Vieytes, M. R., Alfonso, A., and Louzao, M. C. (1992) Nonimmunological release of histamine from rat mast cells elicited by antineoplastic agents: effect of drug combinations, Cancer Chemother. Pharmacol. 30, 487-490.
[58] Botana, L. M., Arnaez, E., Vieytes, M. R., Alfonso, A., Bujan, M. J., Louzao, M. C., and Cabado, A. (1992) Non-immunological release of histamine from rat mast cells elicited by antineoplastic agents, Cancer Chemother. Pharmacol. 29, 495-498.
[59] Botana, L. M., Alfonso, A., Louzao, M. C., and Vieytes, M. R. (1992) Effect of the phorbol esther TPA on the Na+/H+ exchanger in rat mast cells., Dendron 1, 109-117.
[60] Botana, L. M., Alfonso, A., Botana, M. A., Vieytes, M. R., Louzao, M. C., and Cabado, A. G. (1992) Influence of protein kinase C, cAMP and phosphatase activity on histamine release produced by compound 48/80 and sodium fluoride on rat mast cells, Agents Actions 37, 1-7.
[61] Arnaez, E., Alfonso, A., Estevez, M., Vieytes, M. R., Louzao, M. C., and Botana, L. M. (1992) Effect of purification, theophylline and sodium fluoride on histamine release produced by antineoplastic drugs on rat mast cells. A distinctive mechanism of action for carboplatin, Biochem. Pharmacol. 44, 533-538.
[62] Vieytes, M. R., Louzao, M. C., de la Cruz, L. F., and Botana, L. M. (1991) [Effect of isoproterenol on the liberation of histamine from rat lung mast cells], Rev. Esp. Fisiol. 47, 13-17.
[63] Vieytes, M. R., Louzao, M. C., Bujan, M. J., Alfonso, A., Cabado, A., de la Cruz, L. F., and Botana, L. M. (1991) Lack of specific saxitoxin binding to rat mast cells, Agents Actions 33, 92-93.
[64] Vieytes, M. R., de la Cruz, L. F., and Botana, L. M. (1991) [Inhibition of histamine liberation in mast cells from the lung and the intestine of the dog by isoproterenol], Rev. Esp. Fisiol. 47, 19-24.
[65] Vieytes, M. R., Alfonso, A., Bujan, M. J., Louzao, M. C., Cavado, A., de la Cruz, L. F., and Botana, L. M. (1991) Changes in rat mast cell responses in sodium-free media. Lack of demonstrable sodium channel activity, Agents Actions 33, 94-96.
[66] Louzao, M. C., Román, A., De la Cruz, L. F., Vieytes, M. R., and Botana, L. M. (1990) Ligamiento de STX a fragmentos de membrana procedentes de células del mejillón Mytilus galloprovincialis, In III Congreso Nacional Acuicultura (Pesca, C. d., Ed.), pp 599-603., Xunta de Galicia, Santiago de Compostela.
[67] Louzao, M. C., Román, A., De la Cruz, L. F., Vieytes, M. R., and Botana, L. M. (1990) Estudio comparativo del ligamiento de STX en rata, cangrejo y mejillón, In Actas III Congreso Nacional Acuicultura (Pesca, C. d., Ed.), pp 605-609, Xunta de galicia, Santiago de Compostela.
[68] Eleno, N., Botana, L., and Espinosa, J. (1990) K-channel blocking drugs induce histamine release and 45Ca uptake in isolated mast cells, Int. Arch. Allergy Appl. Immunol. 92, 162-167.
[69] Hirst, B. H., Botana, L. M., Arilla, E., and Coy, D. H. (1988) Somatostatin structure-activity studies in the stomach, Horm. Res. 29, 79-82.
[70] Eleno, N., Botana, L. M., and Espinosa, J. (1988) El mastocito. Una célula de fisiología desconocida e implicaciones patológicas conocidas., 1 ed., Santiago de Compostela.
[71] Eleno, N., Botana, L., Espinosa, J., and Fernandez-Otero, M. P. (1988) [Effect of colchicine on histamine secretion and calcium uptake in mast cells], Rev. Esp. Fisiol. 44, 35-40.
[72] Eleno, N., Botana, L., and Espinosa, J. (1988) Veratridine elicits histamine release and promotes calcium uptake in mast cells, Biochem. Pharmacol. 37, 3523-3525.
[73] Eleno, N., Botana, L., and Espinosa, J. (1988) Dual effect of dihydropyridines on 45Ca uptake induced by the K+ -channel blocker, 4-aminopyridin on mast cells, J. Cell. Physiol. 137, 378-383.
[74] Botana, L. M., Espinosa, J., Eleno, N., Botana, M. A., and Fernandez-Otero, M. P. (1988) [Effect of NaF and calcium in rats mastocytes in response to norepinephrine], Rev. Esp. Fisiol. 44, 105-106.
[75] Eleno, N., Orallo, F., Botana, L., Espinosa, J., and Cadavid, I. (1987) Hydralazine-relaxing effect on rat aorta is not mediated through changes in ATPase activity, Arch. Int. Pharmacodyn. Ther. 285, 72-79.
[76] Eleno, N., Botana, L., Segura, C., and Espinosa, J. (1987) Valinomycin, a degranulating agent in rat mast cells which inhibits calcium-uptake, Agents Actions 22, 189-196.
[77] Botana, L. M., Fernández, A. J., and Jover, A. (1987) Cambios morfológicos inducidos por la Polimixina B y Adrenalina en mastocitos pleurales y peritoneales de ratón., Acta Microscópica 10, 177-182.
[78] Botana, L. M., Espinosa, J., and Eleno, N. (1987) Adrenergic activity on rat pleural and peritoneal mast cells. Loss of beta-receptors during the purification procedure, Gen. Pharmacol. 18, 141-148.
[79] Botana, L. M. (1987) Adrenergic agonists do not compete with the antagonist (-)3-[125I]iodocyanopindolol for binding to rat pleural or peritoneal mast cell adrenergic receptor, Gen. Pharmacol. 18, 263-267.
[80] Eleno, N., Espinosa, J., and Botana, L. M. (1986) Secreción de histamina inducida por el compuesto 48/80 en mastocitos: requerimientos metabólicos durante la exocitosis, Ann. Real Acad. Farmacia 52, 349-354.
[81] Eleno, N., Botana, L. M., Segura, C., and Espinosa, J. (1986) Decreased histamine release from pleural and peritoneal rat mast cells activated with sodium fluoride in the presence of bovine serum albumin, Bol. Acad. Gall. Ciencias 5, 91-96.
[82] Eleno, N., Botana, L. M., Segura, C., and Espinosa, J. (1986) Histamine release induced by Concanavalin A in two rat mast cell populations, Acta Cient. Compost. 23, 211-221.
[83] Eleno, N., Botana, L. M., Espinosa, J., Segura, C., Taboada, C., and Fernandez-Otero, P. (1986) [Na+ K+ ATPase activity in mast cells from the pleural and peritoneal cavities of the rat], Rev. Esp. Fisiol. 42, 85-89.
[84] Eleno, N., Botana, L. M., Espinosa, J., Segura, C., and Fernández-Otero, M. P. (1986) Estudio de la actividad Na+-K+ ATPasa en mastocitos de las cavidades pleural y peritoneal de rata, Rev. Esp. Fisiol. 42, 85-90.
[85] Eleno, N., Botana, L. M., and Espinosa, J. (1986) Secreción de histamine inducida por el compuesto 48/80 en ausencia de glucosa en mastocitos de rata, Bol. Acad. Gall. Ciencias 5, 83-90.
[86] Eleno, N., Botana, L. M., and Espinosa, J. (1986) Regulación de la secreción de histamina por flujos iónicos, Ann. Real Acad. Farm. 52, 741-746.
[87] Botana, L. M., Orallo, F., Espinosa, J., and Calleja, J. M. (1986) In vivo inhibition of polymyxin B-induced hypotension: evidence of beta-adrenergic inhibitory activity on rat mast cells, Gen. Pharmacol. 17, 615-618.
[88] Botana, L. M., Espinosa, J., Segura, C., Taboada, C., and Fernández-Otero, M. P. (1986) Desensitization of rat mast cell beta-adrenergic receptors: desensitization by incubation for increased times with isoproterenol, IRCS Med. Sci. 14, 9-10.
[89] Botana, L. M., Espinosa, J., Segura, C., and Fernández-Otero, M. P. (1986) Differences in adenylate cyclase activity on rat pleural and peritoneal mast cells: lack of correlation between cAMP levels and histamine release, IRCS Med. Sci. 14, 11-12.
[90] Botana, L. M., Espinosa, J., and Fernandez-Otero, M. P. (1986) [Response of pleural and peritoneal mastocyte populations in the rat to agents with different mechanisms of action], Rev. Esp. Fisiol. 42, 449-453.
[91] Botana, L. M., Eleno, N., Espinosa, J., and Fernandez-Otero, M. P. (1986) Effect of calcium on histamine release from pleural and peritoneal mast cells induced by catechol, Rev. Esp. Fisiol. 42, 455-458.
[92] Botana, L. M., Eleno, N., and Espinosa, J. (1986) Lack of correlation between the onset of cAMP levels due to beta adrenergic agonists and their effect on rat pleural and peritoneal rat mast cell response, Bol. Acad. Gall. Ciencias 5, 97-104.
[93] Botana, L. M. (1986) [Is the existence of negative interactions between mastocyte populations possible?], Arch. Farmacol. Toxicol. 12, 153-156.
[94] Taboada, M. C., Andrés, M. D., Botana, L. M., and Fernández-Otero, M. P. (1985) Influx and efflux of leucine in isolated epithelia cells of the chick: effect of somatostatin, IRCS Med. Sci. 13, 1076-1077.
[95] Botana, L. M., Sáinz, V., Criado, M. T., Ferreirós, C. M., Espinosa, J., and Fernández-Otero, M. P. (1985) Increased release of histamine from rat mast cells stimulated with compound 48/80 in the presence of Neisseria meningitidis, IRCS Med. Sci. 13, 593-594.
[96] Botana, L. M., Espinosa, J., Eleno, N., Segura, C., and Fernandez-Otero, P. (1985) Difference in, and influence of the purification medium on, sensitivity and maximum response of peritoneal and pleural mast cells stimulated by certain polyamines, Agents Actions 16, 342-345.
[97] Botana, L. M. (1985) Mediación adrenérgica en la regulación de la actividad secretora de los mastocitos de rata, Universidad de Santiago de Compostela.
[98] Segura, C., Espinosa, J., Botana, L. M., and Fernández-Otero, M. P. (1984) Actividad acetilcolinesterasa en los islotes de Langerhans de la rata, Bol. Acad. Gall. Ciencias 3, 87-94.
[99] Espinosa, J., Botana, L. M., Puentes, E., and Regueiro, B. J. (1984) Milk progesterone radioimmunoassay using radioiodinated tracers: a rapid and reliable assay system, Steroids 44, 217-228.
[100] Espinosa, J., Botana, L. M., and Fernandez-Otero, M. P. (1983) [Secretory activity of mast cells in the presence of cholinergic agonists], Rev. Esp. Fisiol. 39, 441-445.
[101] Espinosa, J., Botana, L. M., Eleno, N., Segura, C., and Fernández-Otero, M. P. (1983) Evidence against the presence of cholinergic activity on pleural and peritoneal rat mast cells, Bol. Acad. Gall. Ciencias 2, 53-55.
[102] Botana, L. M., Espinosa, J., and Fernandez-Otero, M. P. (1983) [Isolation of mastocytes from rat peritoneal fluid using continuous Ficoll gradients], Rev. Esp. Fisiol. 39, 435-440.